Spatial Epidemiology of Tuberculosis (TB) Infection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00780546
Recruitment Status : Unknown
Verified October 2008 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
First Posted : October 27, 2008
Last Update Posted : October 27, 2008
Information provided by:
National Taiwan University Hospital

Brief Summary:
Data will be extracted from the NTUH medical records database, geocoded according to the street address so that the case number, incidence, etc could be mapped. The spatial data would be used to detect aggregation of TB cases, existence of "hot spots" and then determine if they may merit further investigation or may have occurred by chance. The results from these GIS-based analyses would address local variations in TB incidence and transmission.

Condition or disease

Detailed Description:

This is a Geographic Information System (GIS)-based retrospective study. Data will be extracted from the NTUH medical records database, including the date of notification, sex, birth date, residence address, etc of each tuberculosis case. Each case will be geocoded to generate spatial coordinates for mapping purpose based on the street address and postal code. To protect the privacy of these patients, the personal identification data of TB patients, including name and ID numbers, will not be encoded. The encoded data file will also be strictly kept confidential.

Disease mapping is the usual means of presenting descriptive geographic data on disease occurrence and creating accurate maps of disease morbidity and mortality. Maps convey instant visual information on the spatial distribution of disease and can identify subtle patterns which may be missed in tabular presentations. The purpose is to display variations in ill-health (for example, related to the underlying sociodemography), formulate etiologic hypotheses, aid surveillance to detect areas of high disease incidence, and help place specific disease.

In detecting the spatial patterns of the points geocoded from the addresses, point pattern analytical methods are used. Quadrat Analysis is one of them. This method evaluates a case distribution by examining how its density changes over space. The density measured by Quadrat Analysis is then compared with the density of a theoretically constructed random pattern to see if the case distribution in question is more clustered or more dispersed than the random pattern. Another one is Nearest Neighbor Statistic, which is derived from the average distance between cases and each of their nearest neighbors and captures information on cases between quadrats. Using ordered neighbor statistic can evaluate the pattern at different spatial scales. A case pattern is said to be more clustered if its observed average distance between nearest neighbors is found to be less than that of a random pattern. Ripley's K statistic is an extension of the ordered neighbor statistics, which can be used to depict the randomness of a case distribution over different spatial scales and capture the characteristic of local variations.

To measure and test how dispersed/clustered the case locations are with respect to their attribute values, e.g. socioeconomic status, spatial autocorrelation can be performed. If significant positive spatial autocorrelation exists in a case distribution, cases with similar characteristics tend to be near each other.

For polygon data in interval or ratio form, such as the tuberculosis incidence of different districts, Moran's I index, Geary's Ratio and the G-statistic can be used. Moran's I uses the mean of the attribute's data values as the benchmark for comparison when neighboring values are evaluated; Geary's Ratio is based on a direct comparison of neighboring values; G-statistic is based on the concept of spatial association or cross-product statistics and is capable of detecting the presence of hot spots or cold spots. In case of spatial heterogeneity, i.e. the magnitude of spatial autocorrelation varies over space, modified versions of the previous three statistics can be used to evaluate spatial association at the local scale.

Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Ecologic or Community
Time Perspective: Retrospective
Official Title: Spatial Epidemiology of Tuberculosis Infection
Study Start Date : October 2008
Estimated Primary Completion Date : May 2009
Estimated Study Completion Date : July 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tuberculosis
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
NTUH patients

Inclusion Criteria:

  • TB patients of NTUH

Exclusion Criteria:

  • TB patient whose address cannot be geocoded

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00780546

Contact: In Chan Ng, Bachelor

National Taiwan University Hospital Active, not recruiting
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Chi-Tai Fang, PhD National Taiwan University
Study Director: Tzai-Hung Wen, PhD National Taiwan University
Principal Investigator: In Chan Ng, bachelor National Taiwan University

Responsible Party: Institute of Epidemiology Identifier: NCT00780546     History of Changes
Other Study ID Numbers: 200808047R
First Posted: October 27, 2008    Key Record Dates
Last Update Posted: October 27, 2008
Last Verified: October 2008

Keywords provided by National Taiwan University Hospital:
spatial epidemiology
geographic information system

Additional relevant MeSH terms:
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections