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C-Reactive Protein (CRP) Gene Variants and Coronary Artery Disease in a Chinese Han Population (CRP-Han)

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ClinicalTrials.gov Identifier: NCT00780221
Recruitment Status : Unknown
Verified October 2008 by Fudan University.
Recruitment status was:  Recruiting
First Posted : October 27, 2008
Last Update Posted : October 27, 2008
Information provided by:
Fudan University

Brief Summary:
The recognition of the association between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD) has led to an increased emphasis on CRP genetic effects on CRP level and CHD. However, the causality of CRP variants remains uncertain.The objective of this study is to evaluate the association of CRP gene variants and CRP levels in CHD in Chinese Han population. We conduct case-control study in CRP-Han study participants. The common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels are detected. A Mendelian randomization analysis will be used to help test the likelihood of causal association of gene-CRP levels, CRP levels-CHD and gene-CHD. The investigators hypothesize that CRP gene variants influence the protein level and may participate in CHD progress.

Condition or disease
Coronary Artery Disease

Detailed Description:
CHD patients and non-CHD population are recruited. CRP level and CHD severity by coronary angiograph will be examined. Mendelian randomization analysis are taken to analyze statically.

Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: CRP Gene Variants and Coronary Artery Disease in a Chinese Han Population
Study Start Date : October 2008
Estimated Primary Completion Date : October 2010
Estimated Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

U.S. FDA Resources

patients without coronary artery disease
patients with coronary artery disease

Biospecimen Retention:   Samples With DNA
Blood sample will be examined and DNA variants be analyzed.

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
in-hospital patients and community healthy individual

Inclusion Criteria:

  • clinical diagnosis of coronary artery disease

Exclusion Criteria:

  • with major organ disfunction or acute inflammatory disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00780221

Contact: Chaoneng Wu, PhD +86-21-64041990 ext 2152 wuchaoneng@hotmail.com

China, Shanghai
Zhongshan Hospital Recruiting
Shanghai, Shanghai, China, 200032
Contact: Chaoneng Wu    +86-21-64041990 ext 2152    wuchaoneng@hotmail.com   
Sub-Investigator: Chaonneg Wu, PhD         
Principal Investigator: Junbo Ge, PhD,MD         
Sponsors and Collaborators
Fudan University
Study Director: Junbo Ge Shanghai Zhongshan Hospital

Responsible Party: Zhongshan Hospital, Shanghai Institute of Cardiovascular Disease,Zhongshan Hospital
ClinicalTrials.gov Identifier: NCT00780221     History of Changes
Other Study ID Numbers: ZSJQ-30725036
First Posted: October 27, 2008    Key Record Dates
Last Update Posted: October 27, 2008
Last Verified: October 2008

Keywords provided by Fudan University:
coronary artery disease

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases