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Impact of Preoperative Chemotherapy on Complications and Regeneration After Resection of Colorectal Liver Metastases

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00779272
First Posted: October 24, 2008
Last Update Posted: October 24, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Zurich
  Purpose
The objective of this study is to evaluate for the first time not only the impact of neoadjuvant chemotherapy on clinical outcome, but also on liver regeneration after liver resection.

Condition
Colorectal Liver Metastases

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Impact of Preoperative Chemotherapy on Complications and Regeneration After Resection of Colorectal Liver Metastases

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Postoperative Complications and liver regeneration [ Time Frame: 2003- July 2008 ]

Estimated Enrollment: 184
Study Start Date: September 2008
Study Completion Date: October 2008
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Without preoperative chemotherapy
2
With preoperative chemotherapy

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Records from 184 consecutive patients undergoing liver resection due to colorectal metastases between 2003 and July 2008 were reviewed from a prospective database
Criteria

Inclusion Criteria:

  • Liver resection due to colorectal liver metastases between 2003 and 2007

Exclusion Criteria:

  • Incomplete assessment of preoperative chemotherapy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00779272


Locations
Switzerland
Departement of Visceral and Transplantation Surgery of the University of Zurich
Zurich, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
  More Information

Responsible Party: Breitenstein Stefan, Dr. med., Department Visceral and Transplantation Surgery, University Hospital of Zurich
ClinicalTrials.gov Identifier: NCT00779272     History of Changes
Other Study ID Numbers: StV 29-2008
First Submitted: October 23, 2008
First Posted: October 24, 2008
Last Update Posted: October 24, 2008
Last Verified: October 2008

Keywords provided by University of Zurich:
neoadjuvant chemotherapy
clinically postoperative outcome
liver regeneration after liver resection

Additional relevant MeSH terms:
Neoplasm Metastasis
Liver Neoplasms
Neoplastic Processes
Neoplasms
Pathologic Processes
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases