Heart Rate Variability Change After Liver Transplantation

This study has been completed.

Sponsor:

ClinicalTrials.gov Identifier:

NCT00778687

First Posted: October 23, 2008

Last Update Posted: December 24, 2013

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Information provided by (Responsible Party):

National Taiwan University Hospital

Purpose

Cirrhotic cardiomyopathy describes a hyperdynamic state with the presentation of high cardiac output and low systemic vascular resistance. And the latent heart failure becomes obvious under physiologic and pharmacologic stress. The goal of our study is to assess the effects of liver transplantation on the heart rate variability in patients with end stage liver disease.

Condition
Liver Transplantation


Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Effects of Liver Transplantation on the Heart Rate Variability in Patients With End-Stage Liver Disease

Resource links provided by NLM:

MedlinePlus related topics: Liver Transplantation

U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:

Multiscale entropy [ Time Frame: 6 months ]
Multiscale entropy was measured at nine time points: 1. preoperative, 2. postoperative day 1, 3. postoperative day 2, 4. postoperative day 3, 5. postoperative day 4, 6. postoperative day 7, 7. postoperative day 14, 8. postoperative 3 months, 9. postoperative 6 months


Enrollment:	30
Study Start Date:	October 2008
Study Completion Date:	January 2010
Primary Completion Date:	January 2010 (Final data collection date for primary outcome measure)

Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:	18 Years to 70 Years (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients with end stage liver disease undergoing liver transplantation

Criteria

Inclusion Criteria:

Age:18-70y/o receiving liver transplantation

Exclusion Criteria:

History of cardiovascular disease

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00778687

Locations


Taiwan
National Taiwan University Hospital
Taipei, Taiwan

Sponsors and Collaborators

National Taiwan University Hospital

More Information

Publications:

Genovesi S, Prata Pizzala DM, Pozzi M, Ratti L, Milanese M, Pieruzzi F, Vincenti A, Stella A, Mancia G, Stramba-Badiale M. QT interval prolongation and decreased heart rate variability in cirrhotic patients: relevance of hepatic venous pressure gradient and serum calcium. Clin Sci (Lond). 2009 May 14;116(12):851-9. doi: 10.1042/CS20080325.


Responsible Party:	National Taiwan University Hospital
ClinicalTrials.gov Identifier:	NCT00778687 History of Changes
Other Study ID Numbers:	200809046R
First Submitted:	October 22, 2008
First Posted:	October 23, 2008
Last Update Posted:	December 24, 2013
Last Verified:	December 2013

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