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Assessment of Hematopoietic Recovery Following Chemotherapy for Non-Hodgkin's Lymphoma

This study has been terminated.
(Terminated by institutional review board)
Midwest Medical Isotopes
Information provided by:
University of Oklahoma Identifier:
First received: October 17, 2008
Last updated: September 27, 2010
Last verified: September 2010
A study to determine the accuracy of FLT-PET in quantifying tumor cell proliferation at the initial staging of patients with Non-Hodgkin's Lymphoma in comparison wit the "gold standard" FDG-PET.

Condition Intervention
Non-Hodgkin's Lymphoma Procedure: FLT-PET scan Procedure: FDG-PET scan

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Assessment of Hematopoietic Recovery Following Chemotherapy for Non-Hodgknin's Lymphoma

Resource links provided by NLM:

Further study details as provided by University of Oklahoma:

Primary Outcome Measures:
  • Staging and ReStaging scans [ Time Frame: after hematopoetic recovery ]

Estimated Enrollment: 35
Study Start Date: October 2008
Groups/Cohorts Assigned Interventions
Procedure: FLT-PET scan
imaging scan
Procedure: FDG-PET scan
imaging scan

Detailed Description:
The first primary objective reflects a necessary and preliminary requirement: to reproduce published results and validate the use of FLT-PET. In this study, 35 patients will be selected to undergoing imaging with both FLT and FDG PET.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Subjects diagnosed with lymphoma and are about to start treatment with chemotherapy

Inclusion Criteria:

  • 18 years or older
  • Women must not be pregnant or breast feeding
  • Histologic diagnosis of non-Hodgkin's lymphoma (any stage)
  • Must undergo treatment with chemotherapy and/or radiotherapy

Exclusion Criteria:

  • May not have received previous therapy with radiopharmaceuticals
  • May not have received prior therapy with cytotoxic chemotherapy and/or monoclonal antibodies
  Contacts and Locations
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Please refer to this study by its identifier: NCT00775957

United States, Oklahoma
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Sponsors and Collaborators
University of Oklahoma
Midwest Medical Isotopes
  More Information

Responsible Party: Jennifer Holter, MD, University of Oklahoma Health Sciences Center- Dept. of Medicine Identifier: NCT00775957     History of Changes
Other Study ID Numbers: FLT-NHL
Study First Received: October 17, 2008
Last Updated: September 27, 2010

Additional relevant MeSH terms:
Lymphoma, Non-Hodgkin
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases processed this record on September 21, 2017