Melatonin Production Delay in Preterm Infants
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|ClinicalTrials.gov Identifier: NCT00775723|
Recruitment Status : Completed
First Posted : October 20, 2008
Last Update Posted : November 3, 2008
Objective: Melatonin production is known to be delayed in preterm-born infants up to 6 months of age. This might be related to exposure of preterm infants to continuous lighting in the NICU during a critical period of pineal gland development. The investigators aimed to test the profile of melatonin production in these infants at 9-12 months of age.
Methods: Twenty three term-born and 23 preterm-born infants (gestational age: 29-34 weeks) were studied. The investigators tested nocturnal urinary melatonin excretion, within a repeated measures design, both at 9 and 12 months of age. Nocturnal urine was extracted from diapers and urinary melatonin derivate (6-sulphatoxymelatonin) excretion was analyzed by ELISA assay.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||46 participants|
|Official Title:||Term-Born Infants at 9 and 12 Months of Age: A Randomized Controlled Trial|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||May 2008|
|Actual Study Completion Date :||May 2008|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00775723
|Rambam Medical Center|
|Study Director:||Dr Sari Goldstein Ferber||Sackler School of Medicine, Tel Aviv Universitry|