Melatonin Production Delay in Preterm Infants
Objective: Melatonin production is known to be delayed in preterm-born infants up to 6 months of age. This might be related to exposure of preterm infants to continuous lighting in the NICU during a critical period of pineal gland development. The investigators aimed to test the profile of melatonin production in these infants at 9-12 months of age.
Methods: Twenty three term-born and 23 preterm-born infants (gestational age: 29-34 weeks) were studied. The investigators tested nocturnal urinary melatonin excretion, within a repeated measures design, both at 9 and 12 months of age. Nocturnal urine was extracted from diapers and urinary melatonin derivate (6-sulphatoxymelatonin) excretion was analyzed by ELISA assay.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Term-Born Infants at 9 and 12 Months of Age: A Randomized Controlled Trial|
|Study Start Date:||January 2008|
|Study Completion Date:||May 2008|
|Primary Completion Date:||May 2008 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00775723
|Rambam Medical Center|
|Study Director:||Dr Sari Goldstein Ferber||Sackler School of Medicine, Tel Aviv Universitry|