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Adiponectin and Insulin Resistance in Diabetic Nephropathy

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ClinicalTrials.gov Identifier: NCT00774904
Recruitment Status : Completed
First Posted : October 17, 2008
Last Update Posted : October 20, 2008
Sponsor:
Collaborator:
Shanghai Jiao Tong University School of Medicine
Information provided by:
Health Science Center of Xi’an Jiaotong University

Brief Summary:
Plasma adiponectin concentration is inversely associated with renal function. There is little literature on adiponectin levels and regulation by antihypertensive medication with an angiotensin II-receptor blocker (ARB), especially in subjects with type 2 diabetes in different stage of chronic kidney disease (CKD).

Condition or disease Intervention/treatment Phase
Diabetic Nephropathy Drug: Losartan Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 80 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Adiponectin is Positively Associated With Insulin Resistance in Subjects With Type 2 Diabetic Nephropathy and Effects by Angiotensin Type 1 Receptor Blocker Losartan
Study Start Date : April 2007
Actual Primary Completion Date : October 2007
Actual Study Completion Date : November 2007

Resource links provided by the National Library of Medicine



Intervention Details:
  • Drug: Losartan
    Angiotensin II Type 1 Receptor Blockers


Primary Outcome Measures :
  1. GFR, HbA1c and the adiponectin concentration [ Time Frame: 6 month ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Type 2 diabetic nephropathy
  • CKD at stage 1~4

Exclusion Criteria:

  • Type 1 diabetes or nondiabetic renal disease
  • An elevated plasma K level.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00774904


Locations
China
Shanghai No.3 people's hospital
Shanghai, China, 201900
Sponsors and Collaborators
Health Science Center of Xi’an Jiaotong University
Shanghai Jiao Tong University School of Medicine

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: hui min Jin, shanghai No 3 people's hospital
ClinicalTrials.gov Identifier: NCT00774904     History of Changes
Other Study ID Numbers: ADPN
First Posted: October 17, 2008    Key Record Dates
Last Update Posted: October 20, 2008
Last Verified: October 2008

Keywords provided by Health Science Center of Xi’an Jiaotong University:
Type 2 Diabetes
Diabetic Nephropathy
Glucose Metabolism
Angiotensin II Type 1 Receptor Blockers

Additional relevant MeSH terms:
Diabetic Nephropathies
Insulin Resistance
Kidney Diseases
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Urologic Diseases
Diabetes Complications
Diabetes Mellitus
Endocrine System Diseases
Losartan
Angiotensin II Type 1 Receptor Blockers
Angiotensin II
Anti-Arrhythmia Agents
Antihypertensive Agents
Angiotensin Receptor Antagonists
Molecular Mechanisms of Pharmacological Action
Vasoconstrictor Agents