Ventricular Remodeling In Patients With Aortic Stenosis Assessed Echocardiography

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00774657
Recruitment Status : Withdrawn (Unable to identify and recruit suitable study subjects)
First Posted : October 17, 2008
Last Update Posted : February 17, 2012
Tufts Medical Center
Information provided by (Responsible Party):
Lahey Clinic

Brief Summary:
This preliminary study will compare the effectiveness of two-dimensional and three-dimensional echocardiographic measurements of wall thickness and left ventricular mass in patients with Aortic Stenosis

Condition or disease
Aortic Stenosis

Detailed Description:

This study will evaluate left ventricular patterns of remodeling and hypertrophy in patients with aortic stenosis, and compare two-dimensional echocardiography measurements (wall thickness) with three-dimensional echocardiography data(left ventricular mass). Along with a second objective to assess Doppler diastolic filling indices associated with the various patterns of left ventricular remodeling.

Previous studies(see reference list) were primarily derived from two-dimensional echo data set(based on wall thickness). Various patterns of left ventricular remodeling have been described in response to increased pressure overload.

Three-dimensional echocardiography is a relatively new technique that is being increasingly used in the Echocardiography Lab in selected patients. This technique holds promise of being more accurate for volume-related measurements than the standard 2-dimensional echocardiography techniques.

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Patterns Of Left Ventricular Remodeling In Patients With Aortic Stenosis Assessed By Two-Dimensional And Three-Dimensional Echocardiography
Study Start Date : September 2008
Actual Primary Completion Date : February 2012
Actual Study Completion Date : February 2012

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Evaluate 2-dimensional and 3-dimensional echocardiography for LV patterns of remodeling and hypertrophy [ Time Frame: 1 hour ]

Secondary Outcome Measures :
  1. Assess doppler diastolic filling indices for patterns of LV remodeling [ Time Frame: 1 hour ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Lahey Clinic patients who have been referred to the echocardiography lab for clinical indications, found to have a aortic stenosis

Inclusion Criteria:

  • Subjects more than 18 yrs of age through 90 yrs of age
  • Both male and female
  • Patients with moderate or severe isolated Aortic Stenosis
  • Patients who have been referred for both two-dimensional and three- dimensional echocardiographies.

Exclusion Criteria:

  • Poor acoustic windows
  • h/o CAD and wall motion abnormality

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00774657

United States, Massachusetts
Lahey Clinic, Inc.
Burlington, Massachusetts, United States, 01805
Sponsors and Collaborators
Lahey Clinic
Tufts Medical Center
Principal Investigator: Sherif B. Labib, M.D. Lahey Clinic, Inc.

Responsible Party: Lahey Clinic Identifier: NCT00774657     History of Changes
Other Study ID Numbers: 2008-090
First Posted: October 17, 2008    Key Record Dates
Last Update Posted: February 17, 2012
Last Verified: February 2012

Keywords provided by Lahey Clinic:
Aortic Stenosis
Valvular heart disease
Heart disease
Cardiovascular disease
Two dimensional echocardiography
Three dimensional echocardiography

Additional relevant MeSH terms:
Constriction, Pathologic
Aortic Valve Stenosis
Ventricular Remodeling
Pathological Conditions, Anatomical
Heart Valve Diseases
Heart Diseases
Cardiovascular Diseases
Ventricular Outflow Obstruction