This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Acute Pain and Inflammation After Surgery (Knemikro01)

This study has been completed.
Information provided by (Responsible Party):
Leiv Arne Rosseland, Oslo University Hospital Identifier:
First received: October 16, 2008
Last updated: April 22, 2015
Last verified: April 2015

The purpose of this study is

  1. to observe acute pain after surgery and measure the natural course of inflammatory mediators
  2. study pain relieving effects and local anti-inflammatory effects of systemically administered ketorolac

Condition Intervention Phase
Knee Injuries Drug: 1 Ketorolac intraarticular Drug: Placebo Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Acute Pain and Role of Ketolorac in Inflammatory Mediators After Knee Arthroscopy Evaluated by Microdialysis

Resource links provided by NLM:

Further study details as provided by Leiv Arne Rosseland, Oslo University Hospital:

Primary Outcome Measures:
  • Pain relief local anti-flammatory effects [ Time Frame: 2 h ]

Secondary Outcome Measures:
  • Rescue analgesic consumption [ Time Frame: 2 h ]

Enrollment: 40
Study Start Date: August 2008
Study Completion Date: December 2014
Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Drug: 1 Ketorolac intraarticular
Ketorolac intraarticular 5 mg
Other Names:
  • Ketorolac
  • Saline
Placebo Comparator: 2
Drug: Placebo

Detailed Description:
Randomizized controlled trial

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Day case surgical patients above 18 years old
  • Non pregnant

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00774540

Oslo University Hospital, Division of Emergencies and Critical Care
Oslo, Norway, 0242
Sponsors and Collaborators
Oslo University Hospital
Principal Investigator: Leiv Arne Rosseland Oslo University Hospital
  More Information

Responsible Party: Leiv Arne Rosseland, Professor, Oslo University Hospital Identifier: NCT00774540     History of Changes
Other Study ID Numbers: Knemikro01
Study First Received: October 16, 2008
Last Updated: April 22, 2015

Keywords provided by Leiv Arne Rosseland, Oslo University Hospital:
Acute pain
Inflammatory pain
Inflammatory mediators
Pain relief

Additional relevant MeSH terms:
Acute Pain
Knee Injuries
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Leg Injuries
Wounds and Injuries
Ketorolac Tromethamine
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on September 18, 2017