Pennsylvania Study Of Chronic Obstructive Pulmonary Exacerbations (PA-SCOPE)
The overall purpose of PA-SCOPE is to determine why black and rural residents of Pennsylvania might be at higher risk for deadly, debilitating, and costly hospitalizations for chronic obstructive pulmonary disease (COPD)— and then to show that repeat acute exacerbations in high-risk patients can be reduced with one simple intervention. We believe that 1) COPD patients who are black or who live in rural areas of Pennsylvania are at higher risk of acute exacerbations requiring hospitalization and 2) this elevated risk can be reduced with one simple intervention: access to a 1-800 Temple Call Center where patients can get immediate customized advice on managing COPD exacerbations in their early stages. We will test these beliefs in PA-SCOPE. The collaborators with Temple University Hospital on the PA-SCOPE project are Lancaster General Hospital, Western Pennsylvania Hospital, and the Philadelphia College of Osteopathic Medicine.
Chronic Obstructive Pulmonary Disease
|Official Title:||Pennsylvania Study of Chronic Obstructive Pulmonary Exacerbations (PA-SCOPE)|
- Phase 1 identifies the demographic & genetic factors affecting inpatient hospitalization for COPD exacerbation.Phase 2 documents the number of physician & ER visits, hospitalizations & death related to exacerbations. [ Time Frame: Phase 1 is up to 10 weeks. Phase 2 is up to 2 years. ] [ Designated as safety issue: No ]
- Phase 2 also documents the number, severity, & subject reporting of exacerbations, spirometry changes,& quality of life. [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Ancillary studies collect blood specimens for gene expression and genetic factors.
|Study Start Date:||June 2004|
|Study Completion Date:||May 2008|
|Primary Completion Date:||May 2008 (Final data collection date for primary outcome measure)|
Phase 1 & Gene Expression:Hospitalized COPD exacerbators
Phase 2: COPD group
Genetic Association Studies: COPD and Healthy Controls
- Overall objective: To determine why African American and rural residents of Pennsylvania might be at higher risk for deadly, debilitating, and costly hospitalizations for COPD—and to show that repeat acute exacerbations in high-risk patients can be reduced with one simple intervention--access to a 1-800 Temple Call Center phone number where patients can get immediate customized advice on managing COPD exacerbations in their early stages.
- Phase 1: To compare and contrast the influence of race and geographic location in COPD exacerbation in relation to severity, comorbidities, treatment patterns, infection rate. To identify potential risk factors for COPD exacerbations leading to hospitalization.
- Phase 2: To reduce hospitalizations and deaths due to COPD exacerbations and to improve patient quality of life, lung function, and everyday activity levels
Please refer to this study by its ClinicalTrials.gov identifier: NCT00774176
|United States, Pennsylvania|
|Lancaster General Hospital|
|Lancaster, Pennsylvania, United States, 17604|
|Temple University School of Medicine|
|Philadelphia, Pennsylvania, United States, 19140|
|Western Pennsylvania Hospital|
|Pittsburgh, Pennsylvania, United States, 15224|
|Principal Investigator:||Gerard J Criner, MD||Temple University|