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Identification of Novel Targets for Regulation of Adipose Tissue Mass

This study has been completed.
Swiss Federal Institute of Technology
Information provided by (Responsible Party):
Gottfried Rudofsky, University of Heidelberg Identifier:
First received: October 15, 2008
Last updated: August 22, 2012
Last verified: August 2012
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

Condition Intervention
Dietary Supplement: Optifast

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Identification of Novel Targets for Regulation of Adipose Tissue Mass

Resource links provided by NLM:

Further study details as provided by Heidelberg University:

Primary Outcome Measures:
  • number of adipocytes and preadipocytes under weight loss [ Time Frame: three years ]

Secondary Outcome Measures:
  • metabolic function of adipocytes and preadipocytes under weight loss [ Time Frame: three years ]

Enrollment: 62
Study Start Date: October 2008
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Patients included take part at a weight reduction program over one year.
Dietary Supplement: Optifast
Formula diet for twelve weeks combined with physical activity and behavioral therapy


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Participants of the OPTIFAST52 program
  • BMI > 30 kg/m2

Exclusion Criteria:

  • Rejection of informed consent by the participant
  Contacts and Locations
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Please refer to this study by its identifier: NCT00773565

University Hospital Heidelberg
Heidelberg, Germany, 69115
Sponsors and Collaborators
Gottfried Rudofsky
Swiss Federal Institute of Technology
Study Chair: Christian Wolfrum, PhD University of Zurich
  More Information

Responsible Party: Gottfried Rudofsky, Oberarzt, University of Heidelberg Identifier: NCT00773565     History of Changes
Other Study ID Numbers: EFSD-CRP-2008
Study First Received: October 15, 2008
Last Updated: August 22, 2012

Keywords provided by Heidelberg University:
patients with obesity (BMI > 30 kg/m2) processed this record on May 22, 2017