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Inter Individual Variation in Weight Loss Response to Exercise

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ClinicalTrials.gov Identifier: NCT00773214
Recruitment Status : Completed
First Posted : October 16, 2008
Last Update Posted : February 6, 2015
Information provided by (Responsible Party):

Study Description
Brief Summary:

The identification and characterization of individuals who vary in their response to exercise-induced weight loss is important. Weight loss in response to exercise is variable and it remains unknown who will succeed, why, and more importantly how to improve weight loss efficacy.

This study will examine changes in behavioural, metabolic, physiological and biochemical variables in response to a 12 week supervised exercise programme and evaluate their association with weight loss in overweight and obese sedentary individuals.

Our hypothesis is that changes in the plasma levels of appetite related hormones undermine the inter individual variation in weight loss in response to exercise.

This study will improve the understanding of variability to exercise-induced weight loss and allow more individually tailored and appropriate strategies for weight management programmes.

Condition or disease Intervention/treatment
Obesity Behavioral: Exercise

Detailed Description:

Purpose - To identify predictors of weight loss in overweigh/obese volunteers following a 12 week supervised exercise programme, and to characterise the variability in weight loss response.

Method - Longitudinal study aiming to identify predictors of weight loss in response to a 12-week exercise programme in healthy overweight/obese volunteers.

Subjective and objective measures of appetite, cardiovascular fitness, anthropometry, body composition, resting metabolic rate (RMR), fat and carbohydrate oxidation in the fasting state will be measured at baseline, before participants enroll for the study and after the exercise intervention.

The preload/test-meal paradigm (using a high and low-energy preload: HEP vs LEP) will be used to assess short-term appetite control before and after the exercise intervention following a randomized single-blinded crossover design. Moreover, the long-term effects of exercise on cytokine plasma levels and fasting and postprandial levels of appetite related hormones/metabolites will also be assessed at baseline and end of the study. Participants will act as their own controls throughout the study.

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Identification and Characterization of Individual Variability in Exercise-induced Weight Loss: Biological and Behavioral Markers of Success.
Study Start Date : April 2008
Primary Completion Date : February 2009
Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: exercise Behavioral: Exercise
12-week supervised exercise programme (5 times /week at 75% maximal Heart Rate)

Outcome Measures

Primary Outcome Measures :
  1. Changes in fasting and postprandial plasma levels of appetite related hormones [ Time Frame: Baseline and after a 12 week exercise intervention ]

Secondary Outcome Measures :
  1. Changes in body weight and body composition [ Time Frame: Baseline and after a 12-week exercise intervention ]

Eligibility Criteria

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 25<BMI<35 Kg/m2
  • weight stable on the last three months (<2kg)
  • not currently dieting to lose weight
  • with an inactive lifestyle (not engaged in strenuous work or in regular brisk leisure time exercise more than once a week or in light exercise for more than 20 minutes/day in more than 3 times/week)

Exclusion Criteria:

  • History of endocrine/cardiovascular/pulmonary/kidney disease, anaemia, gout, depression or other psychological disorders
  • Eating disorders
  • Drug or alcohol abuse within the last two years
  • Current medication known to affect appetite or induce weight loss.
  • Those with a planned surgery during the study period or participating in another research study will also not be accepted to take part in this study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00773214

Norwegian University of Science and Technology
Trondheim, Norway, 7030
Sponsors and Collaborators
Norwegian University of Science and Technology
Fundação para a Ciência e a Tecnologia
Principal Investigator: Catia Martins, BSc, MSc, PhD Norwegian University of Science and Technology
More Information

Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT00773214     History of Changes
Other Study ID Numbers: 18926
First Posted: October 16, 2008    Key Record Dates
Last Update Posted: February 6, 2015
Last Verified: February 2015

Keywords provided by Norwegian University of Science and Technology:
Body composition
Energy compensation

Additional relevant MeSH terms:
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms