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Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?

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ClinicalTrials.gov Identifier: NCT00773032
Recruitment Status : Unknown
Verified October 2008 by University of California, San Diego.
Recruitment status was:  Recruiting
First Posted : October 16, 2008
Last Update Posted : October 16, 2008
Sponsor:
Information provided by:
University of California, San Diego

Brief Summary:

The purpose of this study is to investigate whether

  1. pharmacologically enhanced naps will show increases in specific sleep stages
  2. whether these sleep stages will produces specific increases on memory tests
  3. whether older adults will benefit more than young adults from increased SWS or Stage 2 on subsequent declarative and motor memory tests.

Condition or disease Intervention/treatment Phase
Older Adults Drug: Sodium Oxybate Drug: Zolpidem Drug: placebo Not Applicable

Study Type : Interventional  (Clinical Trial)
Study Start Date : October 2008
Estimated Primary Completion Date : June 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Club Drugs

Arm Intervention/treatment
Experimental: Sodium Oxybate
2.5g Sodium Oxybate administered during nap
Drug: Sodium Oxybate
2.5g Sodium Oxybate administered during nap

Experimental: Zolpidem
5mg Zolpidem administered during nap
Drug: Zolpidem
5mg Zolpidem administered during nap

Placebo Comparator: Placebo Drug: placebo
Placebo administered during nap





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Ages Eligible for Study:   60 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • English-speaking individuals, half men and half women, and between the ages of 60 and 75 years will be recruited. No ethnic group will be specifically excluded from study. All participants will be recruited from general San Diego Community. An education requirement of at least 12 years completed will be imposed, as education may affect performance on the cognitive task.

Exclusion Criteria:

  • Not having a regular sleep-wake schedule (defined as not meeting criteria listed above and/or a Horne-Ostberg Morningness-Eveningness Questionnaire score not between 31-69)
  • Having a sleep disorder (reported or detected on the questionnaires)
  • Any personal or immediate family (i.e., first degree relative) history of diagnosed significant psychopathology
  • Personal history of head injury with loss of consciousness greater than 15 minutes or seizures
  • History of substance dependence
  • Current use of any psychotropic medications
  • Any cardiac, respiratory or other medical condition which may affect cerebral metabolism
  • Given the nature of the stimulus and its presentation, anyone with non-correctable vision and audition impairments will also be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00773032


Contacts
Contact: Jen Kanady, BA 858-642-3192 jkanady@vapop.ucsd.edu

Locations
United States, California
Laboratory for Sleep and Behavioral Neuroscience Recruiting
La Jolla, California, United States, 92093
Contact: Jen Kanady, BA    858-642-3192    jkanady@vapop.ucsd.edu   
Sponsors and Collaborators
University of California, San Diego

Responsible Party: PI: Sara C. Mednick Ph.D.
ClinicalTrials.gov Identifier: NCT00773032     History of Changes
Other Study ID Numbers: 071529_OA
First Posted: October 16, 2008    Key Record Dates
Last Update Posted: October 16, 2008
Last Verified: October 2008

Additional relevant MeSH terms:
Zolpidem
Sodium Oxybate
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
GABA-A Receptor Agonists
GABA Agonists
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Adjuvants, Anesthesia
Anesthetics, Intravenous
Anesthetics, General
Anesthetics