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Canadian Anticoagulant Percutaneous Coronary Intervention Registry (CAPCIR)

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ClinicalTrials.gov Identifier: NCT00773006
Recruitment Status : Completed
First Posted : October 16, 2008
Last Update Posted : October 5, 2011
Information provided by (Responsible Party):
Robert Welsh, University of Alberta

Brief Summary:
Advances in mechanical intervention (PCI) and anticoagulation therapy have been the cornerstone of treatment of patients with coronary artery disease. However, the large diversity of approaches to anticoagulation during PCI introduces gaps in knowledge regarding management of cardiac patients. As such, we have initiated a national PCI registry to elucidate anticoagulant choice, dosing strategies, case selection dynamics, and clinical outcomes in the Canadian health care environment.

Condition or disease
Coronary Artery Disease

Study Type : Observational
Actual Enrollment : 747 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Canadian Prospective, Observational Study on the Use of LMWH in the Setting of Percutaneous Coronary Intervention
Study Start Date : February 2008
Primary Completion Date : June 2010
Study Completion Date : September 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Stable/elective PCI patients
NSTEMI PCI patients
STEMI PCI patients

Primary Outcome Measures :
  1. Description of anticoagulant management during PCI and current practices of participating centres will be undertaken [ Time Frame: in-hospital ]

Secondary Outcome Measures :
  1. In-hospital safety outcomes including - major, minor bleeding, requirement for transfusion, death, myocardial infarction (or re-MI), myocardial ischemia requiring urgent revascularization, and major bleeding [ Time Frame: in-hospital ]
  2. In-hospital angiographic complications: no reflow, thrombus, occlusion of collateral branches, distal embolism, coronary dissection, acute closure of the culprit vessel [ Time Frame: in-hospital ]
  3. PCI-related resources utilization during the study period, including cost of PCI and its treatment (e.g. duration of hospital stay, drug costs, costs related to bleeding such as transfusions) [ Time Frame: in-hospital ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
UA, STEMI and NSTEMI ACS patients treated prior to PCI with LMWH and/or patients treated with LMWH during PCI i.e. in catheterization laboratory.

Inclusion Criteria:

  1. 18 or more years of age.
  2. Undergoing PCI during treatment with LMWH
  3. Provision of written and informed consent

Exclusion Criteria:

  1. Language, medical, or psychiatric barriers that preclude understanding of informed consent process.
  2. Patients in which the site investigator is unable to comply with completion of study documentation following PCI, i.e. patients with planned transfer to another hospital not participating in the registry.
  3. Enrollment in a clinical trial involving another anticoagulant agent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00773006

Canada, Alberta
University of Alberta
Edmonton, Alberta, Canada, T6G 2B7
Sponsors and Collaborators
University of Alberta

Responsible Party: Robert Welsh, Associate Professor, University of Alberta
ClinicalTrials.gov Identifier: NCT00773006     History of Changes
Other Study ID Numbers: CAPCIR02474
First Posted: October 16, 2008    Key Record Dates
Last Update Posted: October 5, 2011
Last Verified: October 2011

Keywords provided by Robert Welsh, University of Alberta:
coronary artery disease
percutaneous coronary intervention

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases