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The Use of Statins for Myocardial Death Prevention

This study has been completed.
Information provided by (Responsible Party):
N_Krivoy, Rambam Health Care Campus Identifier:
First received: October 11, 2008
Last updated: May 25, 2012
Last verified: May 2012
The administration of high dose HMG-CoA reductase inhibitors (Statins) to patients with acute ST-elevation MI (hypoxia/ischemia) who are treated with primary PCI (reoxygenation/ reperfusion) will protect their cardiomyocytes from death and thus preserve LV ejection fraction.

Condition Intervention Phase
Myocardial Infarction Drug: Atorvastatin Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Use of Statins for Myocardial Death Prevention: From Cell to Bedside

Resource links provided by NLM:

Further study details as provided by N_Krivoy, Rambam Health Care Campus:

Primary Outcome Measures:
  • Heart EcoCardiography and specific laboratory tests [ Time Frame: Base line, second day and 60 days after myocardial infarction ]

Enrollment: 25
Study Start Date: August 2008
Study Completion Date: August 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Atorvastatin 80 mg Drug: Atorvastatin
Oral Atorvastatin
Experimental: Atorvastatin 10 mg Drug: Atorvastatin
Oral Atorvastatin


Ages Eligible for Study:   30 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

1. Patients suffering from acute ST elevation resulting from myocardial infarction, Killip Classification 1 and 2 will be included at-random to either group. Included subjects should be able to give their informed consent to participate in this study.

Exclusion Criteria:

  1. The impossibility to give the required informed consent.
  2. Known allergy to Atorvastatin.
  3. Base line serum creatinine of 1.4 mg/dL.
  4. Killip Classification 3 and 4.
  5. Persisting vomiting.
  6. History of previous liver disease.
  7. History of previous muscle disease or rabdomyolisis.
  8. Treated already with high dose atorvastatin
  9. Non Compliance.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00772564

Rambam Health Care Campus
Haifa, Israel, 31096
Sponsors and Collaborators
Rambam Health Care Campus
Principal Investigator: Sammer Diab, MD, PhD Rambam Health Care Campus
  More Information

Responsible Party: N_Krivoy, Clinical Pharmacology Unit, Rambam Health Care Campus Identifier: NCT00772564     History of Changes
Other Study ID Numbers: Ator2685Hdm2[2]
Study First Received: October 11, 2008
Last Updated: May 25, 2012

Keywords provided by N_Krivoy, Rambam Health Care Campus:
Acute ST Elevation Myocardial Infarction

Additional relevant MeSH terms:
Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Atorvastatin Calcium
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors processed this record on June 22, 2017