Radical Prostatectomy and Perioperative Fluid Therapy
The optimal amount of fluid a patient need under surgery is not clear. Both to much and to little fluid can damage the organ functions.
A strategy called "Goal directed therapy", where the fluid amount a patient need is guided by the stroke volume, has shown to minimize post-operative nausea and vomiting.
The investigators intend to investigate if patients treated after these standards, has a better outcome then patients treated after normal regimes, regarding post-operative orthostatic-intolerance.
|Prostate Cancer||Procedure: Standard therapy Procedure: Maximization of cardiac stroke volume with fluid infusion||Phase 4|
|Study Design:||Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Radical Prostatectomy and Perioperative Fluid Therapy|
- To investigate orthostatic cardiovascular response and orthostatic intolerance in patients after removal of the prostate [ Time Frame: 6 hours ]
- Investigate intraoperative haemodynamics [ Time Frame: Intraoperative ]
|Study Start Date:||October 2008|
|Study Completion Date:||October 2009|
|Primary Completion Date:||October 2009 (Final data collection date for primary outcome measure)|
|Placebo Comparator: Standard treatment||
Procedure: Standard therapy
|Active Comparator: SV maximization||
Procedure: Maximization of cardiac stroke volume with fluid infusion
Maximization of cardiac stroke volume with fluid infusion
Please refer to this study by its ClinicalTrials.gov identifier: NCT00771966
|Dept of anesthesiology, Rigshospitalet|