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Peripheral Metabolic Effects of Ghrelin

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ClinicalTrials.gov Identifier: NCT00771940
Recruitment Status : Completed
First Posted : October 15, 2008
Last Update Posted : February 3, 2009
Information provided by:

Study Description
Brief Summary:
The aim of this study is to investigate putative peripheral effects of ghrelin on glucose and lipid metabolism in healthy men. Eight subjects will be enrolled. The hypothesis is that ghrelin infusion causes insulin resistance and lipolysis.

Condition or disease Intervention/treatment Phase
Healthy Controls Drug: Ghrelin Phase 1

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 8 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Peripheral Metabolic Effects of Intra Arterial Ghrelin Infusion in Healthy Controls
Study Start Date : October 2008
Primary Completion Date : January 2009
Study Completion Date : January 2009
Arms and Interventions

Arm Intervention/treatment
Active Comparator: Ghrelin Drug: Ghrelin
Solvent, cont. infusion

Outcome Measures

Primary Outcome Measures :
  1. Plasma levels of glucose [ Time Frame: During study day ]

Secondary Outcome Measures :
  1. Insulin signaling [ Time Frame: Study day ]
  2. Serum levels of fatty acids [ Time Frame: Study day ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. BMI < 27 kg/m2
  2. Written informed consent
  3. Non-smoker

Exclusion Criteria:

  1. Any disease including epilepsy
  2. Any use of medications (excl. paracetamol)
  3. Present or previous malignancy
  4. Alcohol dependency
  5. Allergy to any trial medication
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00771940

Aarhus University Hospital
Aarhus, Denmark, Dk-8000
Sponsors and Collaborators
University of Aarhus
Study Director: Jens Otto L. Jorgensen, MD Medical Department M, Aarhus University Horpital, Denmark
Principal Investigator: Esben T Vestergaard, PhD Medical Department M, Aarhus University Hospital, Denmark
More Information

Responsible Party: Jens Otto Lunde Jorgensen/MD Professor and Esben T. Vestergaard/MD PhD, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00771940     History of Changes
Other Study ID Numbers: M-2007008
First Posted: October 15, 2008    Key Record Dates
Last Update Posted: February 3, 2009
Last Verified: February 2009