Osteoarthritis and Body Composition: Evaluation of Systematic Mediators
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|ClinicalTrials.gov Identifier: NCT00771082|
Recruitment Status : Terminated
First Posted : October 10, 2008
Last Update Posted : June 6, 2012
|Condition or disease|
Banked serum and urine specimens obtained from NIA Baltimore Longitudinal Study on Aging (BLSA) participants with and without knee OA will be used to determine inflammatory, metabolic, bone and joint biomarkers in an observational, case-control study. This study will be limited to BLSA data and samples that have already been acquired and stored.
The specific aims of this study are to:
- Examine the association between prevalent radiographic osteoarthritis (OA), concurrently obtained inflammatory and metabolic mediator levels and change in bone density and bone markers over time subsequent to radiographic classification.
- Determine levels of inflammatory, metabolic and bone markers, and body composition when radiographic OA was absent, and examine their relationship to the development of radiographic knee OA.
Adjustments will be made for age, gender, body mass index and level of physical activity.
|Study Type :||Observational|
|Actual Enrollment :||1033 participants|
|Observational Model:||Case Control|
|Official Title:||Osteoarthritis and Body Composition: Evaluation of Systematic Mediators|
|Study Start Date :||January 2003|
|Estimated Primary Completion Date :||December 2012|
|Estimated Study Completion Date :||December 2012|
- Changes in inflammatory marker c-reactive protein [ Time Frame: 3 to 5 years ]
- Changes in other biomarkers: inflammatory, metabolic, bone, and joint [ Time Frame: 3 to 5 years ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00771082
|United States, Maryland|
|National Institute on Aging|
|Baltimore, Maryland, United States, 21225|
|Principal Investigator:||Shari Ling, MD||National Institute on Aging (NIA)|