Mannheim Obesity Study (MOS)
Recruitment status was: Recruiting
MOPS: Mannheim Obesity Pilot Study
Obesity is a central feature of the metabolic syndrome. With increasing prevalence of overweight and obesity, the incidence of WHO III° obesity will further augment. In this subset of obese patients, metabolic complications and cardiovascular risk are major clinical issues. Epidemiological data show that with increased BMI mortality rises (1). The SOS-Study demonstrated, for the first time, that bariatric surgery and consecutive weight reduction are associated with a decrease in cardiovascular and overall mortality. Significant mortality in this study was caused by cardiovascular events and cancer.
Metabolic Syndrome - MS - Despite varying definitions of the metabolic syndrome, obesity is one of its central features. Depending on the definition used, it can represent an obligate criterion (IDF) or a facultative parameter (WHO and ATP III). Even though not obligate, extreme obesity is a central risk factor for most other parameters of the metabolic syndrome.
Endothelial dysfunction -ED- represents the initial step of atherosclerosis (3). An appropriate measurement is the evaluation by retinal analysis. Epidemiological data demonstrate increased cardiovascular risk with retinal vessel pathology (4).
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Mannheim Obesity Pilot Study: Evaluation of Metabolic Und Cardiovascular Risk in Obesity|
- Metabolic syndrome [ Time Frame: baseline, after 1 and 2 years ]
- Framingham risk score [ Time Frame: baseline, 1 and 2 years ]
- Subclinical atherosclerosis (IMT) [ Time Frame: baseline, 1 and 2 years ]
- Endothelial dysfunction [ Time Frame: baseline, 1 and 2 years ]
- Change in body weight [ Time Frame: baseline, 1 and 2 years ]
|Study Start Date:||January 2005|
|Estimated Study Completion Date:||January 2017|
|Estimated Primary Completion Date:||January 2015 (Final data collection date for primary outcome measure)|
diet and exercise
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00770276
|University hospital of Mannheim|
|Mannheim, BW, Germany, 68167|