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Mannheim Obesity Study (MOS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00770276
Recruitment Status : Unknown
Verified January 2018 by Alexander Lammert, Universitätsmedizin Mannheim.
Recruitment status was:  Active, not recruiting
First Posted : October 9, 2008
Last Update Posted : January 4, 2018
Information provided by (Responsible Party):
Alexander Lammert, Universitätsmedizin Mannheim

Brief Summary:

MOPS: Mannheim Obesity Pilot Study


Obesity is a central feature of the metabolic syndrome. With increasing prevalence of overweight and obesity, the incidence of WHO III° obesity will further augment. In this subset of obese patients, metabolic complications and cardiovascular risk are major clinical issues. Epidemiological data show that with increased BMI mortality rises (1). The SOS-Study demonstrated, for the first time, that bariatric surgery and consecutive weight reduction are associated with a decrease in cardiovascular and overall mortality. Significant mortality in this study was caused by cardiovascular events and cancer.

Metabolic Syndrome - MS - Despite varying definitions of the metabolic syndrome, obesity is one of its central features. Depending on the definition used, it can represent an obligate criterion (IDF) or a facultative parameter (WHO and ATP III). Even though not obligate, extreme obesity is a central risk factor for most other parameters of the metabolic syndrome.

Endothelial dysfunction -ED- represents the initial step of atherosclerosis (3). An appropriate measurement is the evaluation by retinal analysis. Epidemiological data demonstrate increased cardiovascular risk with retinal vessel pathology (4).

Condition or disease

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Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Mannheim Obesity Pilot Study: Evaluation of Metabolic Und Cardiovascular Risk in Obesity
Study Start Date : January 2005
Estimated Primary Completion Date : February 2018
Estimated Study Completion Date : January 2020

Bariatric surgery
Bariatric surgery
conservative Therapie
diet and exercise

Primary Outcome Measures :
  1. Metabolic syndrome [ Time Frame: baseline, after 1 and 2 years ]
  2. Framingham risk score [ Time Frame: baseline, 1 and 2 years ]
  3. Subclinical atherosclerosis (IMT) [ Time Frame: baseline, 1 and 2 years ]
  4. Endothelial dysfunction [ Time Frame: baseline, 1 and 2 years ]

Secondary Outcome Measures :
  1. Change in body weight [ Time Frame: baseline, 1 and 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 88 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
outpatient department of an university hospital

Inclusion Criteria:

  • obesity WHO I-III

Exclusion Criteria:

  • pregnancy
  • acute vascular event within the last 3 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00770276

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University hospital of Mannheim
Mannheim, BW, Germany, 68167
Sponsors and Collaborators
Universitätsmedizin Mannheim
Publications of Results:
Other Publications:

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Alexander Lammert, Dr. med., Universitätsmedizin Mannheim Identifier: NCT00770276    
Other Study ID Numbers: MOS
First Posted: October 9, 2008    Key Record Dates
Last Update Posted: January 4, 2018
Last Verified: January 2018
Keywords provided by Alexander Lammert, Universitätsmedizin Mannheim:
obesity WHO I-III
metabolic syndrome
Framingham risk score
subclinical atherosclerosis
endothelial dysfunction
Additional relevant MeSH terms:
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Nutrition Disorders
Body Weight