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Removal of Uremic Toxins With Nocturnal Dialysis Versus Standard Dialysis

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Ghent
ClinicalTrials.gov Identifier:
NCT00766792
First received: October 3, 2008
Last updated: October 30, 2008
Last verified: October 2008
  Purpose
Dialysis patients, who decide to switch from standard dialysis (3 times 240-270 min/week) to nocturnal dialysis (3 times 480 min/week), will be followed. In parallel a control group with patients staying on standard dialysis will be followed. The study will last 30 weeks. During this period blood samples (pre- and post-dialysis: 10 times; inlet and outlet of dialyzer: 3 times) will be collected on predetermined time points. Concentration of several uremic retention solutes will be determined.

Condition Intervention
Chronic Renal Failure
Procedure: Nocturnal dialysis
Procedure: Standard dialysis

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Removal of Uremic Toxins With Nocturnal Dialysis Versus Standard Dialysis

Further study details as provided by University Hospital, Ghent:

Primary Outcome Measures:
  • To evaluate what is more effective for removal of uremic toxins - nocturnal versus standard dialysis? [ Time Frame: 30 weeks ]

Enrollment: 15
Study Start Date: December 2005
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Nocturnal dialysis
Procedure: Nocturnal dialysis
Switch to nocturnal dialysis (3 times 480 min/week)
Active Comparator: 2
Standard dialysis
Procedure: Standard dialysis
Standard dialysis (3 times 240-270 min/week)

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • age > 18 years

Exclusion Criteria:

  • pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00766792

Locations
Belgium
University Hospital Ghent
Ghent, Belgium, 9000
Sponsors and Collaborators
University Hospital, Ghent
Investigators
Principal Investigator: Raymond Vanholder, MD, PhD University Hospital, Ghent
  More Information

Additional Information:
Responsible Party: Raymond Vanholder, University Hospital Ghent
ClinicalTrials.gov Identifier: NCT00766792     History of Changes
Other Study ID Numbers: 2005/288
Study First Received: October 3, 2008
Last Updated: October 30, 2008

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic

ClinicalTrials.gov processed this record on May 24, 2017