Removal of Uremic Toxins With Nocturnal Dialysis Versus Standard Dialysis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00766792
Recruitment Status : Completed
First Posted : October 6, 2008
Last Update Posted : October 31, 2008
Information provided by:
University Hospital, Ghent

Brief Summary:
Dialysis patients, who decide to switch from standard dialysis (3 times 240-270 min/week) to nocturnal dialysis (3 times 480 min/week), will be followed. In parallel a control group with patients staying on standard dialysis will be followed. The study will last 30 weeks. During this period blood samples (pre- and post-dialysis: 10 times; inlet and outlet of dialyzer: 3 times) will be collected on predetermined time points. Concentration of several uremic retention solutes will be determined.

Condition or disease Intervention/treatment Phase
Chronic Renal Failure Procedure: Nocturnal dialysis Procedure: Standard dialysis Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Removal of Uremic Toxins With Nocturnal Dialysis Versus Standard Dialysis
Study Start Date : December 2005
Actual Primary Completion Date : July 2008
Actual Study Completion Date : July 2008

Arm Intervention/treatment
Experimental: 1
Nocturnal dialysis
Procedure: Nocturnal dialysis
Switch to nocturnal dialysis (3 times 480 min/week)

Active Comparator: 2
Standard dialysis
Procedure: Standard dialysis
Standard dialysis (3 times 240-270 min/week)

Primary Outcome Measures :
  1. To evaluate what is more effective for removal of uremic toxins - nocturnal versus standard dialysis? [ Time Frame: 30 weeks ]

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age > 18 years

Exclusion Criteria:

  • pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00766792

University Hospital Ghent
Ghent, Belgium, 9000
Sponsors and Collaborators
University Hospital, Ghent
Principal Investigator: Raymond Vanholder, MD, PhD University Hospital, Ghent

Additional Information:
Responsible Party: Raymond Vanholder, University Hospital Ghent Identifier: NCT00766792     History of Changes
Other Study ID Numbers: 2005/288
First Posted: October 6, 2008    Key Record Dates
Last Update Posted: October 31, 2008
Last Verified: October 2008

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic