Relationship of Staphylococcal Colonization to Infection
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|ClinicalTrials.gov Identifier: NCT00766259|
Recruitment Status : Unknown
Verified October 2008 by Veterans BioMedical Research Institute.
Recruitment status was: Not yet recruiting
First Posted : October 3, 2008
Last Update Posted : October 3, 2008
Inpatients will be prospectively have nares screened and MRSA strains collected. All clinical MRSA strains of patients will also be prospectively collected. A sensitive strain discrimination test of spa typing will be used to determine if the strains are related. Hypotheses are
- Strain colonization durations vary and may be very short in days to weeks.
- Colonizing strains rarely infect 3) Both 1 and 2 may be affected by the patient's co-morbidity.
|Condition or disease|
Patients of special interest:
- Skin and soft tissue infection
- Nursing home patients
- Vascular patients with leg lesions
- ICU patients
- Hemodialysis patients
- Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year.
All strains will be saved and spa typed. Analysis of the data will be performed to answer the questions and hypotheses and to answer is the screening effort and the isolation of patients for MRSA as is in current practice worthwhile and is there any scientific data to support this practice
|Study Type :||Observational|
|Estimated Enrollment :||4400 participants|
|Observational Model:||Case Control|
|Official Title:||Relationship of Staphylococcal Colonization to Infection|
|Study Start Date :||July 2009|
|Estimated Primary Completion Date :||June 2011|
|Estimated Study Completion Date :||June 2012|
vascular patients with open wounds
control- ambulatory care clinic patients with no infections
- Percent of infection strains which were also colonizer earlier [ Time Frame: 3 years ]
- Duration of strain colonization among co-morbidity cohorts [ Time Frame: 3 years ]
Biospecimen Retention: None Retained