Relationship of Staphylococcal Colonization to Infection
Recruitment status was: Not yet recruiting
Inpatients will be prospectively have nares screened and MRSA strains collected. All clinical MRSA strains of patients will also be prospectively collected. A sensitive strain discrimination test of spa typing will be used to determine if the strains are related. Hypotheses are
- Strain colonization durations vary and may be very short in days to weeks.
- Colonizing strains rarely infect 3) Both 1 and 2 may be affected by the patient's co-morbidity.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Relationship of Staphylococcal Colonization to Infection|
- Percent of infection strains which were also colonizer earlier [ Time Frame: 3 years ]
- Duration of strain colonization among co-morbidity cohorts [ Time Frame: 3 years ]
Biospecimen Retention: None Retained
|Study Start Date:||July 2009|
|Estimated Study Completion Date:||June 2012|
|Estimated Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
vascular patients with open wounds
control- ambulatory care clinic patients with no infections
Patients of special interest:
- Skin and soft tissue infection
- Nursing home patients
- Vascular patients with leg lesions
- ICU patients
- Hemodialysis patients
- Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year.
All strains will be saved and spa typed. Analysis of the data will be performed to answer the questions and hypotheses and to answer is the screening effort and the isolation of patients for MRSA as is in current practice worthwhile and is there any scientific data to support this practice