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The Effect of Neuromuscular Electrical Stimulation (NMES) (NMES)
This study has been completed.
Sponsor:
University of Pittsburgh
Information provided by (Responsible Party):
University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT00765739
First received: October 2, 2008
Last updated: January 23, 2013
Last verified: January 2013
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Purpose
The purpose of this project is to test the effectiveness of neuromuscular electrical stimulation (NMES) that produces 40 % of maximum voluntary contraction (MVC) in increasing muscle size and improvement in muscle force output within the thigh muscle of elderly people.
| Condition | Intervention | Phase |
|---|---|---|
| Muscle Fiber Atrophy, Type II | Other: Neuromuscular electrical stimulation Other: voluntary strengthening exercise | Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single Blind (Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | The Effect of Neuromuscular Electrical Stimulation (NMES) in Inducing Muscle Hypertrophy and Improvement in Muscle Torque Output Within the Quadriceps Muscle of Elderly People |
Resource links provided by NLM:
Further study details as provided by University of Pittsburgh:
Primary Outcome Measures:
- Cross sectional area of type II muscle fibers [ Time Frame: Base line and 3 months follow up ]
Secondary Outcome Measures:
- Quadriceps muscle power output [ Time Frame: baseline and 3 month follow up ]
- Functional performance [ Time Frame: baseline and 3 month follow up ]
- Quadriceps muscle cross sectional area [ Time Frame: baseline and 3 month follow up ]
| Enrollment: | 23 |
| Study Start Date: | October 2008 |
| Study Completion Date: | August 2012 |
| Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
The group who will get neuromuscular electrical stimulation (NMES)
|
Other: Neuromuscular electrical stimulation
neuromuscular electrical stimulation that produce 40% of the maximum voluntary contraction
|
|
Active Comparator: 2
The group who will do the voluntary muscle contraction
|
Other: voluntary strengthening exercise
contracting the quadriceps muscle voluntarily to produce 40% of maximum voluntary contraction
|
Show Detailed Description
Eligibility| Ages Eligible for Study: | 65 Years to 80 Years (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- 65-80 years old, are walking independently without assistive devices.
Exclusion Criteria:
- Uncontrolled hypertension (defined as the following: 1) if not taking BP medication and resting systolic BP is greater than 140 or diastolic greater than 90, or 2) if taking BP medication and resting systolic BP greater than 160 or diastolic greater than 100).
- History of cardiovascular disease
- History of neurological disorders that effect lower extremity function (stroke, peripheral neuropathy, Parkinson's disease, multiple sclerosis)
- One cortico-steroid injection to the quadriceps or patellar tendon in the past month or 3 within the past year.
- History of quadriceps tendon rupture, patellar tendon rupture, or patellar fracture, which could place them at risk of re-injury during quadriceps strength testing.
- Current pain in the knee or in the thigh muscles.
- Diagnosis of inflammatory arthritis (Rheumatoid arthritis, gout, or psoriatic arthritis)
- Muscle diseases such as muscular dystrophy.
- Currently been participating in a regular exercise program more than 1x/week.
- Been using anticoagulants and platelet inhibitors
- History of chronic and significant respiratory disease or shortness of breath
- Visual impairments to the extent that they can not accurately see the monitor screen during training program.
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00765739
Please refer to this study by its ClinicalTrials.gov identifier: NCT00765739
Locations
| United States, Pennsylvania | |
| School of Health and Rehabilitation Sciences | |
| Pittsburgh, Pennsylvania, United States, 15260 | |
Sponsors and Collaborators
University of Pittsburgh
More Information
| Responsible Party: | University of Pittsburgh |
| ClinicalTrials.gov Identifier: | NCT00765739 History of Changes |
| Other Study ID Numbers: |
NMES1 |
| Study First Received: | October 2, 2008 |
| Last Updated: | January 23, 2013 |
Keywords provided by University of Pittsburgh:
|
muscle fibers aging |
Additional relevant MeSH terms:
|
Atrophy Pathological Conditions, Anatomical |
ClinicalTrials.gov processed this record on June 23, 2017