Blood Samples to Evaluate Biomarkers of Donor Chimerism
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We are interested in patient-specific factors that may affect the balance of recipient cells and donor cells in patients who receive stem cell transplants. We will look at the way the patient's body breaks down two drugs, fludarabine and mycophenolate mofetil, and how these two drugs affect the patient's body.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Hematopoietic stem cell transplant patients receiving fludarabine and mycophenolate mofetil.
Diagnosed with a hematologic disease or malignancy
Scheduled to receive nonablative conditioning with fludarabine and total body irradiation
Donor is well-matched by high resolution DNA techniques.
Scheduled to receive postgrafting immunosuppression of oral MMF (CellCept) and an oral calcineurin inhibitor.