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Retrospective Study Evaluating IGF1R And p95HER2 as Prognostic Factors in Non Small Cell Lung Cancer (NSCLC)

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ClinicalTrials.gov Identifier: NCT00763607
Recruitment Status : Completed
First Posted : October 1, 2008
Last Update Posted : September 2, 2010
Sponsor:
Information provided by:

Study Description
Brief Summary:

Aim of the study is to evaluated the role of IGF1R and p95HER2 on prognosis in radically resected non small cell lung cancer patients

The primary objective is to correlate the expression of IGF1R and p95HER2 with survival.


Condition or disease Intervention/treatment
Non Small Cell Lung Cancer Genetic: Protein expression by immunohistochemistry and immunofluorescence

Study Design

Study Type : Observational
Estimated Enrollment : 454 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Study Evaluating IGF1R And p95HER2 as Prognostic Factors in Radically Resected Non Small Cell Lung Cancer
Study Start Date : November 2007
Primary Completion Date : February 2008
Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Cancer
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
1
Radically resected Non small cell lung cancer patients in stage I-III
Genetic: Protein expression by immunohistochemistry and immunofluorescence
Protein expression by immunohistochemistry and immunofluorescence


Outcome Measures

Primary Outcome Measures :
  1. Association of different biomarkers with survival [ Time Frame: At the end of enrollment ]

Secondary Outcome Measures :
  1. Association of a specific biomarker with patient's characteristics [ Time Frame: At the end of enrollment ]

Biospecimen Retention:   Samples With DNA
Paraffine embedded tumor sections

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Radically resected non small cell lung cancer patients
Criteria

Inclusion Criteria:

  • Radically resected non small cell lung cancer patients with tumor tissue available

Exclusion Criteria:

  • Tumor tissue not available
  • Clinical data not available
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00763607


Locations
Italy
Istituto Clinco Humanitas
Rozzano, Milan, Italy, 20089
Sponsors and Collaborators
Istituto Clinico Humanitas
Investigators
Principal Investigator: Armando Santoro, MD Istituto Clinico Humanitas
More Information

Responsible Party: Armando Santoro, MD, Istituto Clinico Humanitas
ClinicalTrials.gov Identifier: NCT00763607     History of Changes
Other Study ID Numbers: ONC/OSS-02/2007
First Posted: October 1, 2008    Key Record Dates
Last Update Posted: September 2, 2010
Last Verified: September 2010

Keywords provided by Istituto Clinico Humanitas:
non small cell lung cancer patients

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms