Unnecessary IV Antibiotic Days Using General Criteria for Antibiotic Switch
|ClinicalTrials.gov Identifier: NCT00763373|
Recruitment Status : Completed
First Posted : September 30, 2008
Last Update Posted : September 30, 2008
|Condition or disease||Intervention/treatment||Phase|
|Infection||Other: Implementation of antibiotic switch guidelines||Phase 3|
The study is a comparison of the use of intravenous antibiotics before and after the implementation of switch criteria. Switch is defined as a change in administration route from intravenous to oral.
Patients administered to medical department at Sorlandet hospital in Kristiansand and Arendal are included if they are receiving intravenous antibiotics. Pediatric department is not included. Patients that are already hospitalized and given intravenous antibiotics are also included.
Patients that are excluded are those with CNS-infection, endocarditis, bone/joint infection, deep undrainable abscesses and those with foreign body infection.
Switch criteria are made from a thorough investigation on earlier switch studies. We have collected several studies on this topic, but none from the nordic countries.
The intervention contributes the following: The implementation of a registration form where doctors are prone to answer six questions when they evaluate antibiotic administration form.
- Are there special iv-indications? (CNS-infection, endocarditis, bone/joint infection, deep undrainable abscesses or foreign body infection)
- Is the oral route compromized? (unconscious, nausea, vomiting, diarrhoea, dysphagia, lack of cooperativeness)
- Is the patients suffering from immunosuppression? (leukopenia, cytotoxic treatment, transplantation, steroids >10mg, TNF-alfa inhibitor treatment, unregulated diabetes mellitus (HbA1C >10), uremia (serum-creatinine > 300), HIV, AIDS, lymphoma, multiple myelomas, cystic fibrosis, asplenic)
- Is the systemic inflammatory response syndrome present?
- Is the preferred antibiotics only available in intravenous form?
- Are there any other special reasons for intravenous antibiotics?
If the doctor can answer NO to all these questions, then the patient is a candidate for antibiotic switch from day three after hospitalization. This evaluation form follows the other medical registration forms from day to day.
The intervention also includes
- A lecture by the study group to all our medical doctors.
- Information by e-mail to all our medical doctors
- Information by letters to all our medical doctors and chief nurses
Registration of parameters used for evaluating antibiotic switch is done three times a week by the study group. We register date and patient information, if other medication is taken orally, heart rate, respiratory rate, temperature, biochemical parameters (CRP and leukocytes), diagnosis and antibiotic choice.
|Study Type :||Observational|
|Actual Enrollment :||187 participants|
|Official Title:||Unnecessary IV Antibiotic Days Using General Criteria for Antibiotic Switch|
|Study Start Date :||November 2006|
|Primary Completion Date :||January 2007|
|Study Completion Date :||March 2007|
Other: Implementation of antibiotic switch guidelines
Implementation of antibiotic switch guidelines
Other Name: Antibiotic switch
- Reduction in the amount of intravenous antibiotic days [ Time Frame: During stay ]
- Hospital stay duration, re-admittance, re-prescription of intravenous antibiotic therapy [ Time Frame: 4 weeks ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00763373
|Sorlandet Sykehus Arendal|
|Arendal, Aust-Agder, Norway, 4500|
|Sørlandet Sykehus Kristiansand|
|Kristiansand, Vest Agder, Norway, 4604|
|Principal Investigator:||Bjoern Waagsboe, Ass dr||Medical department Kristiansand|
|Study Director:||Anders Sundoy, Chief Doc||Medical dep kristiansand|
|Study Director:||Else Quist Paulsen, ass doc||Med dep Arendal|