Spine Quantitative Computed Tomography (QCT) (Spine QCT)
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ClinicalTrials.gov Identifier: NCT00762879 |
Recruitment Status
:
Completed
First Posted
: September 30, 2008
Last Update Posted
: October 3, 2017
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Condition or disease |
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Juvenile Idiopathic Arthritis |
Study Type : | Observational |
Actual Enrollment : | 127 participants |
Observational Model: | Case-Control |
Time Perspective: | Cross-Sectional |
Official Title: | Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children |
Study Start Date : | April 2008 |
Actual Primary Completion Date : | January 2014 |
Actual Study Completion Date : | June 2017 |

Group/Cohort |
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No treatment |
- Lumbar spine volumetric Bone Mineral Density (vBMD) and vertebral size will vary according to sex, age and pubertal stage. [ Time Frame: same day ]
- Children with JIA will have lower vertebral stiffness and strength, compared with controls. [ Time Frame: same day ]
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 5 Years to 21 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- for JIA patients: subjects age 5-21 Drawn from Dr. Burnham's prospective cohort study of bone health in 101 children with arthritis.
- for Control patients: subjects age 5-21 Controls will be a 50% male/female
Exclusion Criteria:
- for JIA patients: Subjects with JIA will be excluded if they have conditions or drug exposure unrelated to JIA and known to impact growth or bone health.
- for Control patients: Chronic disease or syndrome known to affect growth or bone health, prematurity (<37 weeks gestation), or use of any medication known to affect growth.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00762879
United States, Pennsylvania | |
The Children's Hospital of Philadelphia | |
Philadelphia, Pennsylvania, United States, 19104 |
Principal Investigator: | Jon Burnham, MD | Children's Hospital of Philadelphia |
Responsible Party: | Children's Hospital of Philadelphia |
ClinicalTrials.gov Identifier: | NCT00762879 History of Changes |
Other Study ID Numbers: |
07-005528 |
First Posted: | September 30, 2008 Key Record Dates |
Last Update Posted: | October 3, 2017 |
Last Verified: | September 2017 |
Keywords provided by Children's Hospital of Philadelphia:
Juvenile Idiopathic Arthritis JIA Arthritis Osteoporosis Osteoporosis in Children |
Additional relevant MeSH terms:
Arthritis Osteoporosis Arthritis, Juvenile Joint Diseases Musculoskeletal Diseases Bone Diseases, Metabolic |
Bone Diseases Metabolic Diseases Rheumatic Diseases Connective Tissue Diseases Autoimmune Diseases Immune System Diseases |