Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients
This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.
Transcutaneous Carbon Dioxide
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Compare the Side Effects and Differences Awake Level of Propofol by Using Three TCI Formula of Anesthesia in TVOR Patients|
- Vital signs changes and side effects of drugs among groups [ Time Frame: pre-anesthesia, post-anesthesia, and one hour post-anesthesia ] [ Designated as safety issue: No ]
- Correlation between transcutaneous carbon dioxide and BIS (bispectral index) [ Time Frame: From drug infusion stopped to patients awake (per minute) ] [ Designated as safety issue: No ]
|Study Start Date:||September 2008|
|Study Completion Date:||December 2008|
|Primary Completion Date:||October 2008 (Final data collection date for primary outcome measure)|
pure propofol by TCI pump with titration.
10ug/kg alfentanyl bolus and propofol TCI pump infusion with titration
20ug/kg alfentanyl bolus and propofol TCI pump infusion with titration
Transvaginal oocyte retrieval (TVOR) is a procedure often used in infertility women . During the procedure, sedation, analgesia or anesthesia are often required. Propofol and alfentanyl are used for these patients for years, but these drugs are used in intravenous form and can be found in follicular fluid. Although further investigation needs to be undertaken to investigate any potential influence on fertilization and implantation rates, we anesthesiologist want to lower the use of drugs in these women. Target-controlled infusion (TCI) pumps can estimate and calculate the target and plasma concentration of propofol. By using these pumps , we can estimate the stable concentration of drugs. Besides, Bispectral index (BIS) monitor can help us to evaluate awareness or unarousable amnesia when we turn lower the drug use and keep patients amnesia during the procedure. Transcutaneous carbon dioxide monitor (tcCO2) can mimic the level of CO2 in patients by using noninvasive method. During anesthesia, CO2 will retain and may induce CO2 nacrosis, so we use these noninvasive method to help us to detect CO2 level preventing CO2 nacrosis and to see if there are any relationship with BIS.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00760253
|Department of Anesthesiology, National Taiwan University Hospital|
|Study Director:||Chuen-shin Jeng, MD, MS||Visiting staff|