Endothelial Function in Lower Extremity Bypass Grafts
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|ClinicalTrials.gov Identifier: NCT00759707|
Recruitment Status : Completed
First Posted : September 25, 2008
Results First Posted : April 6, 2017
Last Update Posted : May 16, 2017
|Condition or disease||Intervention/treatment||Phase|
|Peripheral Arterial Disease||Drug: L-N^G monomethyl arginine (L-NMMA)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||19 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Single (Outcomes Assessor)|
|Masking Description:||Investigators who analyzed the results of vascular function testing were blinded to the participant identity.|
|Primary Purpose:||Basic Science|
|Official Title:||Endothelial Function in Lower Extremity Bypass Grafts|
|Study Start Date :||April 2006|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||December 2009|
ultrasound imaging of saphenous vein bypass graft following an ischemic stimulus, administration of sublingual nitroglycerin and intravenous administration of L-NMMA.
Drug: L-N^G monomethyl arginine (L-NMMA)
L-NMMA was infused at a dose of 1 mg/kg over 10 minutes to competitively inhibit the production of nitric oxide. Ultrasound imaging of the saphenous vein [arterial] bypass at baseline, and following an ischemic stimulus, administration of sublingual nitroglycerin, and intravenous administration of L-NMMA.
- Change From Baseline in Saphenous Vein Bypass Graft Vasodilation [ Time Frame: Single visit study ]Flow-mediated, endothelium-dependent vasodilation was determined by comparing baseline vein graft diameter with vein graft diameter as measured after deflation of a 2.5-inch wide sphygmomanometric cuff that had been inflated to suprasystolic pressure for 5 minutes. The cuff was never placed directly over the graft. Vasodilation of the vein graft was determined by acquiring images at 1 minute after cuff deflation.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00759707
|United States, Massachusetts|
|Brigham and Women's Hospital|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Joshua A. Beckman, M.D.||Brigham and Women's Hospital|