Comparison Fetal Hemodynamic Measurements Antihypertensive Versus Control
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ClinicalTrials.gov Identifier: NCT00759278 |
Recruitment Status
: Unknown
Verified September 2008 by State University of New York - Upstate Medical University.
Recruitment status was: Not yet recruiting
First Posted
: September 25, 2008
Last Update Posted
: September 25, 2008
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Condition or disease | Intervention/treatment |
---|---|
Hypertension Pregnancy | Procedure: ultrasound evaluation in pregnancy |

Study Type : | Observational |
Estimated Enrollment : | 60 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Official Title: | A Comparison of Fetal Hemodynamic Measurements Between Pregnant Women Taking Anti-Hypertensive Medication and Controls |
Study Start Date : | August 2008 |
Estimated Primary Completion Date : | August 2010 |
Estimated Study Completion Date : | August 2010 |
Group/Cohort | Intervention/treatment |
---|---|
1
Group of 30 women who are pregnant as subjects that take antihypertensive medication
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Procedure: ultrasound evaluation in pregnancy
Subjects enrolled will have a series of ultrasound evaluations to assess parameters in the study. Ultrasound is a non-invasive technique for creating images that does not use radiation and is routine in obstetrical practice
Other Name: Sonogram
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2
Group of 30 women who are pregnant and do not take antihypertensive medications as a control group
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Procedure: ultrasound evaluation in pregnancy
Subjects enrolled will have a series of ultrasound evaluations to assess parameters in the study. Ultrasound is a non-invasive technique for creating images that does not use radiation and is routine in obstetrical practice
Other Name: Sonogram
|
- Fetal ultrasound assessment of middle cerebral artery and umbilical artery blood flow [ Time Frame: 26 to 33 weeks gestation and 34 to 40 weeks gestational age ]

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- At least 18 years of age
- A diagnosis of chronic hypertension by at least one of these criteria including hypertension that has persisted beyond the postpartum time frame of a prior pregnancy, hypertension diagnosed and managed before current pregnancy, or elevated blood pressure (systolic blood pressure > or = 140 mmHg or diastolic blood pressure > or = 90 mmHg) prior to 20 weeks gestation requiring medication management
- Taking medication for control of chronic hypertension prior to study entry
- Potential subjects taking medications for control of cardiac arrythmia that fall into the anti-hypertensive class will be considered for this cohort
Potential subjects for the control cohort:
- At least 18 years of age
- Absence of a diagnosis of chronic hypertension
- Not taking medication for control of chronic hypertension or arrythmia
Exclusion Criteria:
- Less than 18 years of age
- Pregnancy complicated by significant fetal chromosomal anomaly, severe or multiple fetal anomalies, early onset amniotic fluid abnormalities, preterm labor, placental abruption, or IUGR
- Inability to complete the informed consent process or participate in the study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00759278
Contact: John J Folk, M.D. | 315.464.4736 | folkj@upstate.edu |
United States, New York | |
Regional Perinatal Center University Health Care Center | Not yet recruiting |
Syracuse, New York, United States, 13202 |
Principal Investigator: | John J Folk, M.D. | State University of New York - Upstate Medical University |
Publications:
Responsible Party: | John J. Folk, M.D., SUNY Upstate Medical University |
ClinicalTrials.gov Identifier: | NCT00759278 History of Changes |
Other Study ID Numbers: |
IRBPHS 5215 |
First Posted: | September 25, 2008 Key Record Dates |
Last Update Posted: | September 25, 2008 |
Last Verified: | September 2008 |
Keywords provided by State University of New York - Upstate Medical University:
pregnancy umbilical artery systolic to diastolic flow ratio middle cerebral artery peak systolic flow antihypertensive medication |
Additional relevant MeSH terms:
Antihypertensive Agents |