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Effect of Stress on Heroin-Related Memory Retrieval

This study has been completed.
Information provided by:
National Institute on Drug Dependence, China Identifier:
First received: September 23, 2008
Last updated: NA
Last verified: September 2008
History: No changes posted
The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Condition Intervention
Heroin Dependence Learning and Memory Drug: propranolol and cortisol

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by National Institute on Drug Dependence, China:

Primary Outcome Measures:
  • Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts

Study Start Date: March 2007
Study Completion Date: September 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A, 4 Drug: propranolol and cortisol


Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria:

  • current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).
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Please refer to this study by its identifier: NCT00759005

China, Beijing
National Institute on Drug Dependence
Beijing, Beijing, China, 100191
Sponsors and Collaborators
National Institute on Drug Dependence, China
  More Information Identifier: NCT00759005     History of Changes
Other Study ID Numbers: NIDD
Study First Received: September 23, 2008
Last Updated: September 23, 2008

Additional relevant MeSH terms:
Heroin Dependence
Opioid-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Antihypertensive Agents
Vasodilator Agents processed this record on July 24, 2017