We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Tryptophan Metabolism in Kidney Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00758537
Recruitment Status : Completed
First Posted : September 25, 2008
Last Update Posted : July 14, 2009
Sponsor:
Information provided by:

Study Description
Brief Summary:
Tryptophan metabolism in kidney disease will be investigated in patients with chronic kidney disease stages (ADOQI 3-5). Tryptophan levels and respective catabolites will be assessed under hemodialysis.

Condition or disease
Chronic Kidney Disease

Study Design

Study Type : Observational
Estimated Enrollment : 80 participants
Time Perspective: Prospective
Study Start Date : January 2007
Estimated Study Completion Date : October 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases
Drug Information available for: Tryptophan
U.S. FDA Resources

Groups and Cohorts

Group/Cohort
Patients with chronic kidney disease stage 3
patients with chronic kidney disease stage 4
patients with chronic kidney disease stage 5 (ESRD)
Controls (no kidney disease)


Outcome Measures

Primary Outcome Measures :
  1. Course of plasma tryptophan level and levels of tryptophan metabolites under standard low-flux hemodialysis. [ Time Frame: does not apply ]

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
tertiary care academic center, university hospital
Criteria

Inclusion Criteria:

  • Chronic kidney disease (for > 3months) stages (National Kidney foundation/ADOQI): 3-5

Exclusion Criteria:

  • Signs of infection or systemic inflammation
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00758537


Locations
Germany
Charite University Medicine Berlin
Berlin, Germany, 13353
Sponsors and Collaborators
Charite University, Berlin, Germany
Investigators
Principal Investigator: Petra Reinke, Md PhD Charite University Medicine
More Information

Responsible Party: Prof. Dr. Petra Reinke MD, Charite UNiversity Medicine Berlin, Germany
ClinicalTrials.gov Identifier: NCT00758537     History of Changes
Other Study ID Numbers: TRY1STU
First Posted: September 25, 2008    Key Record Dates
Last Update Posted: July 14, 2009
Last Verified: July 2009

Keywords provided by Charite University, Berlin, Germany:
Assessment of tryptophan and tryptophan catabolites and IDO-activity in patients with chronic kidney disease

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency
Tryptophan
Antidepressive Agents, Second-Generation
Antidepressive Agents
Psychotropic Drugs