Blood Samples From Healthy Volunteers for Genetic Studies in the East Anglia Region of the United Kingdom

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00757991
Recruitment Status : Unknown
Verified September 2008 by National Cancer Institute (NCI).
Recruitment status was:  Recruiting
First Posted : September 23, 2008
Last Update Posted : August 26, 2013
Information provided by:
National Cancer Institute (NCI)

Brief Summary:

RATIONALE: Studying samples of blood from healthy volunteers in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in healthy volunteers.

Condition or disease Intervention/treatment
Healthy, no Evidence of Disease Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: questionnaire administration

Detailed Description:


  • To obtain blood samples and simple epidemiological information on a population-based series of adult individuals without cancer.
  • To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer by comparing the frequency of alterations in these genes with the corresponding frequency in a comparable series of cancer patients.
  • To examine the interactions between genetic and non-genetic risk factors.

OUTLINE: This is a multicenter study.

Participants complete a simple epidemiological questionnaire.

Participants undergo blood sample collection. DNA is extracted from these samples for polymorphism analysis of low penetrance cancer susceptibility genes in the following related clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL.

PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for this study.

Study Type : Observational
Estimated Enrollment : 4000 participants
Official Title: A Population Based Control Collection for Genetic Studies in East Anglia
Study Start Date : February 2008

Primary Outcome Measures :
  1. Acquisition of blood samples and epidemiological information
  2. Investigation of whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer
  3. Examination of the interactions between genetic and nongenetic risk factors

Information from the National Library of Medicine

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Ages Eligible for Study:   35 Years to 69 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes


  • Cancer-free participants randomly selected from the age-sex registry of a general practice in the East Anglia region of the United Kingdom

    • Two general practices from each district within East Anglia participate (up to 10 total participating practices)


  • Identified by the participant's general practitioner as fit to contact for this study
  • No prior diagnosis of cancer
  • No serious mental illness or retardation


  • Not specified

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00757991

United Kingdom
University of Cambridge Cancer Research UK Recruiting
Cambridge, England, United Kingdom, CB1 8RN
Contact: Contact Person    44-122-374-0166   
Sponsors and Collaborators
Cancer Research UK
Study Chair: Paul Pharoah, MD Cancer Research UK Identifier: NCT00757991     History of Changes
Other Study ID Numbers: CDR0000598880
First Posted: September 23, 2008    Key Record Dates
Last Update Posted: August 26, 2013
Last Verified: September 2008

Keywords provided by National Cancer Institute (NCI):
healthy, no evidence of disease