Biomarkers and Genetic Factors Related to Emphysema
|ClinicalTrials.gov Identifier: NCT00757120|
Recruitment Status : Unknown
Verified September 2012 by Washington University School of Medicine.
Recruitment status was: Active, not recruiting
First Posted : September 22, 2008
Last Update Posted : September 17, 2012
|Condition or disease|
|Emphysema Pulmonary Disease, Chronic Obstructive|
COPD is a disease in which the lung is damaged and breathing passages become partly obstructed, making it difficult to breathe. Millions of people in the United States have COPD, and it is the fourth leading cause of death in the country. Symptoms include coughing, excess mucus production, shortness of breath and wheezing. Emphysema and chronic bronchitis are illnesses associated with COPD. Emphysema is usually the result of many years of cigarette smoking, but it remains unknown exactly how cigarette smoking causes emphysema. The purpose of this study is to examine current and former smokers who have emphysema and those who do not have emphysema to determine if certain biomarkers or genetic factors are associated with an increased risk of developing the disease. Specifically, study researchers will examine various genes and two proteins, membrane-type-1 matrix metalloproteinase (MT1-MMP) and extracellular matrix metalloproteinase inducer (EMMPRIN), to determine the role they play in the development of emphysema.
Participants will attend one study visit, which will include a medical history review, a blood collection, lung function testing, a 6-minute walk test, and a chest computed tomography (CT) scan. A portion of blood will be stored for current and future genetic research. Participants will also complete questionnaires to collect information on activities, health, and quality of life. Some participants will be invited to return for a bronchoscopy, which is a procedure that allows a doctor to sample the inside of the lungs. Study researchers will contact all participants at the end of the study to collect follow-up medical information.
|Study Type :||Observational|
|Actual Enrollment :||145 participants|
|Official Title:||SCCOR: Alveolar and Airway Mechanisms for COPD Project 3: Membrane-Type 1 Matrix Metalloproteinase and Extracellular Matrix Metalloproteinase Inducer in Cigarette Smoke-Induced Lung Inflammation and Emphysema Pathogenesis|
|Study Start Date :||October 2007|
|Estimated Primary Completion Date :||February 2013|
|Estimated Study Completion Date :||February 2013|
This group will include current and former smokers who have emphysema.
This group will include current and former smokers who do not have emphysema.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00757120
|United States, Missouri|
|Washington University School of Medicine|
|St. Louis, Missouri, United States, 63110|
|Study Director:||Michael Holtzman, MD||Pulmonary and Critical Care, Washington University in St. Louis|
|Principal Investigator:||Steven Brody, MD||Washington University School of Medicine|