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Pharmacogenetic Study of Methylphenidate in Attention Deficit/Hyperactivity Disorder(ADHD) (NETADHD)

This study has been completed.
Information provided by (Responsible Party):
Hallym University Medical Center Identifier:
First received: September 19, 2008
Last updated: October 4, 2011
Last verified: December 2010
The noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(ADHD).Methylphenidate also has been suspected as a inhibitor of norepinephrine transporter(SLC6A2). The investigators hypothesis is that norepinephrine transporter polymorphism is associated with responses and adverse effects of OROS-methylphenidate in treatment of ADHD.

Condition Intervention Phase
Attention Deficit Disorder With Hyperactivity
Genetic: norepinephrine transporter polymorphism,
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Association Between Norepinephrine Transporter Polymorphism and Response of Methylphenidate

Resource links provided by NLM:

Further study details as provided by Hallym University Medical Center:

Primary Outcome Measures:
  • Korean ADHD Rating scale-parent version (KARS) [ Time Frame: baseline,1,2,4,8 weeks ]

Secondary Outcome Measures:
  • Barkely side effect rating scale [ Time Frame: 1,2,4,8weeks ]

Estimated Enrollment: 150
Study Start Date: October 2005
Study Completion Date: August 2010
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
open label Genetic: norepinephrine transporter polymorphism,
OROS methylphenidate (Concerta) monopharmacotherapy dose : 18-54mg duration : 8 weeks genotyping : norepinephrine transporter (SLC6A2) polymorphism
Other Names:
  • OROS methylphenidate (Concerta) monopharmacotherapy
  • dose : 18-54mg
  • duration : 8 weeks
  • genotyping : norepinephrine transporter (SLC6A2) polymorphism


Ages Eligible for Study:   6 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ADHD
  • Physically healthy

Exclusion Criteria:

  • Neurological illness
  • Concurrent additional psychiatric treatment
  • < IQ 70
  • Psychotic disorder
  • Major mood disorder needed other psychiatric medication
  • Significant suicidal ideation
  • Pervasive developmental disorder
  Contacts and Locations
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Please refer to this study by its identifier: NCT00757029

Korea, Republic of
Hallym University Sacred Heart Hospital
Anyang, Gyeonggi-do, Korea, Republic of
Sponsors and Collaborators
Hallym University Medical Center
  More Information

Responsible Party: Hallym University Medical Center Identifier: NCT00757029     History of Changes
Other Study ID Numbers: NETADHD
Study First Received: September 19, 2008
Last Updated: October 4, 2011

Keywords provided by Hallym University Medical Center:
norepinephrine transporter

Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Autonomic Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Central Nervous System Stimulants
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Dopamine Agents processed this record on May 25, 2017