Study Effect of Red Wine Consumption on Endothelial Progenitor Cells and Endothelial Function

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00755014
Recruitment Status : Completed
First Posted : September 18, 2008
Last Update Posted : September 18, 2008
National Yang Ming University
Information provided by:
Taipei Veterans General Hospital, Taiwan

Brief Summary:
Light-to-moderate alcohol consumption has been associated with a reduction of cardiovascular events, and red wine seems to offer more benefits than any other type of alcoholic beverages. However, the relationship between red wine consumption and endothelial progenitor cells (EPCs) remains unclear. The investigators examine whether intake of red wine could enhance the number or functional capacity of circulating EPCs by upregulation of nitric oxide (NO) bioavailability.

Condition or disease Intervention/treatment Phase
Endothelial Progenitor Cells Numbers Endothelial Function (FMD) Other: red wine Phase 1

Detailed Description:

Moderate ethanol intake from any type of beverage has been shown to improve lipoprotein metabolism and lower cardiovascular mortality risk, but red wine, with its abundant antioxidant contents, seems to confer additional healthy benefits. Previous studies indicated that the beneficial effects of red wine are derived from increased endothelium-derived nitric oxide (NO), implying that enhanced NO bioavailability may mediate the cardiovascular protection provided by red wine.

Increasing evidence suggests that the injured endothelial monolayer is regenerated partly by circulating bone marrow derived-endothelial progenitor cells (EPCs), which accelerate reendothelialization and protect against the initiation and progression of atherosclerosis. Clinical studies demonstrated that the number of circulating EPCs predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk. Although many epidemiologic studies have indicated that light-to-moderate consumption of red wine can reduce the incidence of CAD, the multifarious effects of red wine on circulating EPCs and endothelial function remain to be determined. Therefore, we design this study to test the hypothesis that intake of red wine can enhance the number and functional capacity of EPCs through increasing NO bioavailability.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Taipei Veterans General Hospital
Study Start Date : September 2007
Actual Primary Completion Date : March 2008
Actual Study Completion Date : July 2008

Arm Intervention/treatment
Experimental: 2
Forty subjects are randomized to a group (n=20) that consumed red wine (100 ml) or a group (n=20) that consumed beer (250 ml) daily for 3 weeks
Other: red wine
One group (n=20) that consumed red wine (100 ml) daily for 3 weeks Another group (n=20) that consumed beer (250 ml) daily for 3 weeks
Other Names:
  • The red wine used is "Vin De Pays D'OC" (12.5% ethanol), a cabernet sauvignon from France
  • The beer used was Taiwan Beer (5% alcohol) from Taiwan.

Primary Outcome Measures :
  1. Number of endothelial progenitor cells, endothelial function (FMD) [ Time Frame: VGH-97DHA0100127 ]

Secondary Outcome Measures :
  1. Plasma NO, hsCRP, ADMA, TNF-a, adiponectin, ox-LDL levels [ Time Frame: VGH-97DHA0100127 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Forty young healthy subjects with no cardiovascular risk factors

Exclusion Criteria:

  • History of hypertension
  • Diabetes mellitus
  • Symptoms of CAD
  • Smoking
  • Chronic renal insufficiency (serum creatinine > 1.5 mg/dl)
  • Inflammatory or liver diseases
  • Regular alcohol consumption (drinking more than 20 g of ethanol per week)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00755014

Taipei Veterans Generla Hospital
Taipei, Taiwan, 112
Sponsors and Collaborators
Taipei Veterans General Hospital, Taiwan
National Yang Ming University
Principal Investigator: Shing-Jong Lin, MD, PhD Division of Cardiology, Taipei Veterans General Hospital
Study Director: Po-Hsun Huang, MD Division of Cardiology, Taipei Veterans General Hospital

Responsible Party: Medial Resource and Education, Taipei Veterans General Hospital Identifier: NCT00755014     History of Changes
Other Study ID Numbers: VGHIRB No: 96-01-11A
First Posted: September 18, 2008    Key Record Dates
Last Update Posted: September 18, 2008
Last Verified: September 2008