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Effects of Calcium and Phytate on Zinc Absorption

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ClinicalTrials.gov Identifier: NCT00754390
Recruitment Status : Completed
First Posted : September 18, 2008
Results First Posted : June 8, 2009
Last Update Posted : June 2, 2011
Sponsor:
Information provided by:
USDA Grand Forks Human Nutrition Research Center

Brief Summary:
This study is determine the effects of dietary calcium and phytate on zinc absorption.

Condition or disease Intervention/treatment Phase
Dietary Zinc Absorption Dietary Supplement: Moderate Calcium, Low phytate Diet Dietary Supplement: Moderate Calcium, High Phytate Diet Dietary Supplement: High Calcium, Low Phytate Diet Dietary Supplement: High Calcium, High Phytate Diet Not Applicable

Detailed Description:
Zinc absorption is tested from 2 days of consuming each of four diets with zinc-65 isotope, followed by retention monitoring in a whole body scintillation counter for 4 weeks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 weeks.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 17 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Effects of Calcium and Phytate on Zinc Absorption
Study Start Date : November 2005
Actual Primary Completion Date : May 2006
Actual Study Completion Date : May 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Calcium
U.S. FDA Resources

Arm Intervention/treatment
Experimental: Overall Study
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Dietary Supplement: Moderate Calcium, Low phytate Diet
Participants consumed diet containing 700 milligrams calcium and 440 milligrams of phytate for 4 weeks
Dietary Supplement: Moderate Calcium, High Phytate Diet
Participants consumed diet containing 700 milligrams calcium and 1800 milligrams of phytate for 4 weeks
Dietary Supplement: High Calcium, Low Phytate Diet
Participants consumed diet containing 1900 milligrams calcium and 440 milligrams of phytate for 4 weeks
Dietary Supplement: High Calcium, High Phytate Diet
Participants consumed diet containing 1900 milligrams calcium and 1800 milligrams of phytate for 4 weeks



Primary Outcome Measures :
  1. Zinc Absorption [ Time Frame: 16 weeks ]
    Retention of Zinc-65 was monitored for 28 days by whole body scintillation counting. The percentage of Zinc-65 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic retention plot of percent Zinc-65 retained versus time



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Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Average weight for height

Exclusion Criteria:

  • Medications other than birth control pills or hormone replacement therapy,
  • Pregnancy within last 6 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00754390


Locations
United States, North Dakota
United States Department of Agriculture Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States, 58202
Sponsors and Collaborators
United States Department of Agriculture (USDA)
Investigators
Principal Investigator: Janet R Hunt USDA Grand Forks Human Nutrition Research Center

Responsible Party: Janet R Hunt, Research Nutritiontist, United States Department of Agriculture Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier: NCT00754390     History of Changes
Other Study ID Numbers: GFHNRC042
First Posted: September 18, 2008    Key Record Dates
Results First Posted: June 8, 2009
Last Update Posted: June 2, 2011
Last Verified: May 2011

Keywords provided by USDA Grand Forks Human Nutrition Research Center:
dietary zinc absorption
dietary phytic acid
dietary calcium

Additional relevant MeSH terms:
Calcium, Dietary
Bone Density Conservation Agents
Physiological Effects of Drugs