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Uremic Toxins in the ICU: Patients After Cardiac Surgery

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2015 by University Hospital, Ghent.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00752804
First Posted: September 15, 2008
Last Update Posted: June 3, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University Hospital, Ghent
  Purpose
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients after cardiac surgery.The sampling of blood and dialysate will be done during dialyses with different durations (4, 6 and 8h)

Condition Intervention
Renal Failure Procedure: Dialysis during 4 hours Procedure: Dialysis during 6 hours Procedure: Dialysis during 8 hours

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients After Cardiac Surgery

Resource links provided by NLM:


Further study details as provided by University Hospital, Ghent:

Primary Outcome Measures:
  • Toxin removal [ Time Frame: During dialysis ]

Estimated Enrollment: 12
Study Start Date: September 2008
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Dialysis during 4 hours
Procedure: Dialysis during 4 hours
Blood and dialysate sampling
Active Comparator: 2
Dialysis during 6 hours
Procedure: Dialysis during 6 hours
Blood and dialysate sampling
Active Comparator: 3
Dialysis during 8 hours
Procedure: Dialysis during 8 hours
Blood and dialysate sampling

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ICU patients after cardiac surgery with acute renal failure
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00752804


Contacts
Contact: Sunny Eloot, PhD Sunny.eloot@ugent.be

Locations
Belgium
University Hospital Ghent Recruiting
Ghent, Belgium, 9000
Principal Investigator: Raymond Vanholder, MD, PhD         
Sub-Investigator: Sunny Eloot, PhD         
Sponsors and Collaborators
University Hospital, Ghent
Investigators
Principal Investigator: Raymond Vanholder, MD, PhD University Hospital, Ghent
  More Information

Additional Information:
Responsible Party: University Hospital, Ghent
ClinicalTrials.gov Identifier: NCT00752804     History of Changes
Other Study ID Numbers: 2008/374
First Submitted: September 12, 2008
First Posted: September 15, 2008
Last Update Posted: June 3, 2015
Last Verified: June 2015

Keywords provided by University Hospital, Ghent:
ICU patients with acute renal failure after cardiac surgery

Additional relevant MeSH terms:
Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases