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Uremic Toxins in the ICU: Patients After Cardiac Surgery

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ClinicalTrials.gov Identifier: NCT00752804
Recruitment Status : Unknown
Verified June 2015 by University Hospital, Ghent.
Recruitment status was:  Recruiting
First Posted : September 15, 2008
Last Update Posted : June 3, 2015
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients after cardiac surgery.The sampling of blood and dialysate will be done during dialyses with different durations (4, 6 and 8h)

Condition or disease Intervention/treatment
Renal Failure Procedure: Dialysis during 4 hours Procedure: Dialysis during 6 hours Procedure: Dialysis during 8 hours

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients After Cardiac Surgery
Study Start Date : September 2008
Estimated Primary Completion Date : December 2015
Estimated Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Surgery
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: 1
Dialysis during 4 hours
Procedure: Dialysis during 4 hours
Blood and dialysate sampling
Active Comparator: 2
Dialysis during 6 hours
Procedure: Dialysis during 6 hours
Blood and dialysate sampling
Active Comparator: 3
Dialysis during 8 hours
Procedure: Dialysis during 8 hours
Blood and dialysate sampling


Outcome Measures

Primary Outcome Measures :
  1. Toxin removal [ Time Frame: During dialysis ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ICU patients after cardiac surgery with acute renal failure
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00752804


Contacts
Contact: Sunny Eloot, PhD Sunny.eloot@ugent.be

Locations
Belgium
University Hospital Ghent Recruiting
Ghent, Belgium, 9000
Principal Investigator: Raymond Vanholder, MD, PhD         
Sub-Investigator: Sunny Eloot, PhD         
Sponsors and Collaborators
University Hospital, Ghent
Investigators
Principal Investigator: Raymond Vanholder, MD, PhD University Hospital, Ghent
More Information

Additional Information:
Responsible Party: University Hospital, Ghent
ClinicalTrials.gov Identifier: NCT00752804     History of Changes
Other Study ID Numbers: 2008/374
First Posted: September 15, 2008    Key Record Dates
Last Update Posted: June 3, 2015
Last Verified: June 2015

Keywords provided by University Hospital, Ghent:
ICU patients with acute renal failure after cardiac surgery

Additional relevant MeSH terms:
Renal Insufficiency
Acute Kidney Injury
Kidney Diseases
Urologic Diseases