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The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging (MARATHON-MRI)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00752752
First Posted: September 15, 2008
Last Update Posted: April 3, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Lihua QU, William Beaumont Hospitals
  Purpose
Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon. In addition, the investigators aim to describe the acute and chronic structural abnormalities that occur as a result of endurance training. The study hypothesis is that myocardial necrosis is present in runners completing a marathon competition.

Condition
Myocardial Ischemia Left Ventricular Systolic Dysfunction Elevated Cardiac Enzymes

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging

Resource links provided by NLM:


Further study details as provided by Lihua QU, William Beaumont Hospitals:

Biospecimen Retention:   Samples Without DNA
Serum

Enrollment: 25
Study Start Date: September 2008
Study Completion Date: May 2010
Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
Detailed Description:
MARATHON-MI is a prospective, observational study of twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008. All participants will undergo a rigorous pre-marathon screening process which will include: 1) blood testing, 2) complete cardiopulmonary exercise testing, 3) ECG testing, 4) Holter monitoring, 5) cardiac MRI. Blood work will be check after the marathon immediately after and one day after the event. Cardiac MRI will be repeated within 12 hours of finishing the marathon. Using the information derived from the blood work and radiological testing, we will attempt to determine if there is an association between marathon running and myocardial necrosis.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008.
Criteria

Inclusion Criteria:

  • Detroit Free Press Marathon participant on October 19, 2008,
  • Age > 18 years old,
  • Ability to provide informed consent.

Exclusion Criteria:

  • Known coronary or structural heart disease
  • Pregnancy,
  • Extreme claustrophobia,
  • Metal implants,
  • Renal dysfunction.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00752752


Locations
United States, Michigan
William Beaumont Hospital
Royal Oak, Michigan, United States, 48009
Sponsors and Collaborators
William Beaumont Hospitals
Investigators
Principal Investigator: Justin E Trivax, MD Physician
  More Information

Responsible Party: Lihua QU, Coordinator, William Beaumont Hospitals
ClinicalTrials.gov Identifier: NCT00752752     History of Changes
Other Study ID Numbers: HIC2008-083
First Submitted: September 12, 2008
First Posted: September 15, 2008
Last Update Posted: April 3, 2012
Last Verified: April 2012

Keywords provided by Lihua QU, William Beaumont Hospitals:
Marathon Running
Cardiac Ischemia
Magnetic Resonance Imaging

Additional relevant MeSH terms:
Ischemia
Myocardial Ischemia
Coronary Artery Disease
Ventricular Dysfunction, Left
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arteriosclerosis
Arterial Occlusive Diseases
Ventricular Dysfunction