Diagnosis of Exercise-induced Bronchospasm (EIB) and Asthma in National Collegiate Athletic Association (NCAA) Division I Athletes

This study has been completed.
Sponsor:
Collaborator:
GlaxoSmithKline
Information provided by (Responsible Party):
University of Arizona
ClinicalTrials.gov Identifier:
NCT00752167
First received: September 11, 2008
Last updated: May 10, 2016
Last verified: September 2008
  Purpose
We hypothesize that exercise-induced bronchospasm (EIB) at the NCAA Division I collegiate level is over diagnosed, while poorly controlled asthma resulting in exercise-related symptoms in this same population may be under diagnosed, being erroneously attributed to EIB. This project will test individuals self-identified as having exercise induced bronchospasm or asthma, as well as gender-matched controls from the same sport, with eucapnic voluntary hyperventilation to assess for the presence of EIB or asthma. By making the correct diagnosis, improved health outcomes may be achieved and athletic performance may be enhanced.

Condition
Exercise Induced Bronchospasm, Asthma

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Diagnosis of EIB and Asthma in NCAA Division I Athletes

Resource links provided by NLM:


Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Change in FEV1 following eucapnic voluntary hyperventilation [ Time Frame: 3-21 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Protection from fall in FEV1 following eucapnic voluntary hyperventilation by preadministration of albuterol [ Time Frame: 3-21 minutes ] [ Designated as safety issue: No ]

Enrollment: 74
Study Start Date: February 2007
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
Case
all Division I athletes, male and female, at the University of Arizona that are currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff
Control
control athletes (ie, not currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff and/or not currently using asthma medications) from the same sport

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
NCAA Varsity Division I athletes attending the University of Arizona
Criteria

Inclusion Criteria:

  • varsity athlete
  • ability and willingness to give written informed consent

Exclusion Criteria:

  • inability to give written informed consent
  • unwillingness to perform spirometry or eucapnic voluntary hyperventilation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00752167

Locations
United States, Arizona
University of Arizona
Tucson, Arizona, United States, 85724
Sponsors and Collaborators
University of Arizona
GlaxoSmithKline
Investigators
Principal Investigator: David Millward, MD University of Arizona
  More Information

Publications:
Responsible Party: University of Arizona
ClinicalTrials.gov Identifier: NCT00752167     History of Changes
Other Study ID Numbers: GSK 110189 
Study First Received: September 11, 2008
Last Updated: May 10, 2016
Health Authority: United States: Institutional Review Board
Individual Participant Data  
Plan to Share IPD: No

Keywords provided by University of Arizona:
exercise induced bronchospasm
asthma
athlete
sports
eucapnic voluntary hyperventilation
albuterol

Additional relevant MeSH terms:
Asthma
Bronchial Spasm
Asthma, Exercise-Induced
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on July 26, 2016