Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Diagnosis of Exercise-induced Bronchospasm (EIB) and Asthma in National Collegiate Athletic Association (NCAA) Division I Athletes

This study has been completed.
Information provided by (Responsible Party):
University of Arizona Identifier:
First received: September 11, 2008
Last updated: May 10, 2016
Last verified: September 2008
We hypothesize that exercise-induced bronchospasm (EIB) at the NCAA Division I collegiate level is over diagnosed, while poorly controlled asthma resulting in exercise-related symptoms in this same population may be under diagnosed, being erroneously attributed to EIB. This project will test individuals self-identified as having exercise induced bronchospasm or asthma, as well as gender-matched controls from the same sport, with eucapnic voluntary hyperventilation to assess for the presence of EIB or asthma. By making the correct diagnosis, improved health outcomes may be achieved and athletic performance may be enhanced.

Exercise Induced Bronchospasm, Asthma

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Diagnosis of EIB and Asthma in NCAA Division I Athletes

Resource links provided by NLM:

Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Change in FEV1 following eucapnic voluntary hyperventilation [ Time Frame: 3-21 minutes ]

Secondary Outcome Measures:
  • Protection from fall in FEV1 following eucapnic voluntary hyperventilation by preadministration of albuterol [ Time Frame: 3-21 minutes ]

Enrollment: 74
Study Start Date: February 2007
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
all Division I athletes, male and female, at the University of Arizona that are currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff
control athletes (ie, not currently being treated for either EIB or asthma by review of preparticipation physical forms or identified by the medical staff and/or not currently using asthma medications) from the same sport

  Show Detailed Description


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
NCAA Varsity Division I athletes attending the University of Arizona

Inclusion Criteria:

  • varsity athlete
  • ability and willingness to give written informed consent

Exclusion Criteria:

  • inability to give written informed consent
  • unwillingness to perform spirometry or eucapnic voluntary hyperventilation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00752167

United States, Arizona
University of Arizona
Tucson, Arizona, United States, 85724
Sponsors and Collaborators
University of Arizona
Principal Investigator: David Millward, MD University of Arizona
  More Information

Responsible Party: University of Arizona Identifier: NCT00752167     History of Changes
Other Study ID Numbers: GSK 110189
Study First Received: September 11, 2008
Last Updated: May 10, 2016
Individual Participant Data  
Plan to Share IPD: No

Keywords provided by University of Arizona:
exercise induced bronchospasm
eucapnic voluntary hyperventilation

Additional relevant MeSH terms:
Bronchial Spasm
Asthma, Exercise-Induced
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases processed this record on May 23, 2017