Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis (Pro-Muco)
|ClinicalTrials.gov Identifier: NCT00750932|
Recruitment Status : Completed
First Posted : September 11, 2008
Last Update Posted : February 27, 2017
The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the lung tissue.
The respiratory failure which results from it is one of main causes of the fatal evolution of this pathology but the anti-inflammatory therapies based on the use of antiproteases targeting specifically the soluble elastase did not end, until now, in the hoped results.
The identification of the other noxious targets is a crucial element to give new orientations to the anti-inflammatory strategies based on the administration of antiproteases which remain a promising way.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||52 participants|
|Official Title:||Study of the Biodistribution of PMN Serine Proteases in Sputum of Patients Affected by Cystic Fibrosis: Towards New Anti-inflammatory Therapies|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||January 2012|
|Actual Study Completion Date :||January 2012|
Minor with cystic fibrosis
Adult with cystic fibrosis
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00750932
|CHRU de Tours|
|Tours, France, 37044|
|Principal Investigator:||Patrice DIOT, PHD||Tours Hospital|