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Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00750828
First Posted: September 11, 2008
Last Update Posted: September 11, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hacettepe University
  Purpose
The investigators questioned whether patients with dry mouth complaints display any reduction in residual saliva coating the gingiva and other selected mucosal surfaces. We further intended to test the hypothesis that Gingival Crevicular Fluid volume in patients with dry mouth could be different from that of control subjects. Correlations between gingival/mucosal wetness; and unstimulated whole salivary flow rate or minor salivary gland secretion rates and the correlations between clinical periodontal status and salivary measures were also attempted.

Condition
Xerostomia Sjogren's Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth

Resource links provided by NLM:


Further study details as provided by Hacettepe University:

Enrollment: 28
Study Start Date: January 2004
Study Completion Date: March 2008
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   46 Years to 56 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The data for this study were taken from 28 subjects at the Department of Periodontology, Hacettepe University from 2004 to 2007. The study group consisted of 14 patients with dry mouth complaints. All of them had the diagnosis of Sjögren's syndrome and ten of them were on therapy for sicca symptoms.

Fourteen randomly selected age-matched systemically healthy females were also included as a control group

Criteria

Inclusion Criteria:

  • For test group dry mouth complaints and with a diagnosis ofSjogren's Syndrome

Exclusion Criteria:

  • Other medical problems that effect salivary glands
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00750828


Locations
Turkey
Department of Periodontology, Faculty of Dentistry, Hacettepe University,
Ankara, Turkey, 06100
Sponsors and Collaborators
Hacettepe University
Investigators
Study Director: Burak Demiralp, DDS PhD Hacettepe University Faculty of Dentistry Department of Periodontology
  More Information

Responsible Party: Burak Demiralp, Hacettepe University Faculty of Dentistry Department of Periodontology
ClinicalTrials.gov Identifier: NCT00750828     History of Changes
Other Study ID Numbers: Hacettepe # FON 03/6-14
First Submitted: September 10, 2008
First Posted: September 11, 2008
Last Update Posted: September 11, 2008
Last Verified: September 2008

Keywords provided by Hacettepe University:
Saliva
Sjögren's Syndrome
GCF
Oral Mucosal Wetness

Additional relevant MeSH terms:
Sjogren's Syndrome
Xerostomia
Arthritis, Rheumatoid
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Salivary Gland Diseases
Mouth Diseases
Stomatognathic Diseases
Dry Eye Syndromes
Lacrimal Apparatus Diseases
Eye Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases