Nilotinib Pre and Post Allogeneic Stem Cell Transplantation
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ClinicalTrials.gov Identifier: NCT00750659 |
Recruitment Status :
Completed
First Posted : September 10, 2008
Last Update Posted : April 20, 2016
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Chronic Myeloid Leukemia Acute Lymphoblastic Leukemia Stem Cell Transplantation | Drug: Nilotinib | Phase 2 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 24 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Open-label Trial of Nilotinib in Patients With Advanced (>CP1) Chronic Myeloid Leukemia or Ph+ Acute Lymphatic Leukemia Pre- and Post- Allogeneic Stem Cell Transplantation. |
Study Start Date : | July 2009 |
Actual Primary Completion Date : | April 2016 |
Actual Study Completion Date : | April 2016 |

Arm | Intervention/treatment |
---|---|
Experimental: 1
Nilotinib treatment
|
Drug: Nilotinib
Nilotinib 400 mg po/BID until transplant. Nilotinib 200-400 mg po/BID post transplant in escalated doses. |
- Safety [ Time Frame: 12 months ]
- response [ Time Frame: 12 months ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with Ph+ advanced CML (>CR1) or Ph+ALL.
- Hematological, Cytogenetic (Ph+) and/or BCR/ABL positive documented at diagnosis of CML or Ph+ALL pre- alloSCT.
- Patients age 18-65 years of age.
- .Patients must have an HLA compatible donor willing and capable of donating peripheral blood stem cells (first choice) or bone marrow progenitor cells using conventional techniques, and blood lymphocytes if indicated (HLA compatible defined as 5/6 or 6/6 matched related or matched unrelated donor.
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Adequate end organ function, defined as the following:
total bilirubin < 1.5 x ULN, SGOT and SGPT < 2.5 x UNL , creatinine < 1.5 x ULN
- Patient must have LVEF>45% prior entry into study.
- Patient must have QTc <450 msec at study entry.
- Lung diffusion capacity (DLCO>40% predicted)
- Female patients of childbearing potential must have negative pregnancy test within 7 days before initiation of study drug dosing. Postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential. Male and female patients of reproductive potential must agree to employ an effective barrier method of birth control throughout the study and for up to 3 months following discontinuation of study drug.
- Written, voluntary informed consent.
Exclusion Criteria:
- Patients with CML in first chronic phase
- Patient has received any other investigational agents within 28 days of first day of study drug dosing, unless the disease is rapidly progressing.
- ECOG performance status > 2
- Patient is < 5 years free of another primary malignancy except: if the other primary malignancy is not currently clinically significant nor requiring active intervention, or if other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ. Existence of any other malignant disease is not allowed.
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Impaired cardiac function including any one of the following:
- LVEF < 45% or below the institutional lower limit of the normal range (whichever is higher) as determined by echocardiogram
- Inability to determine the QT interval on ECG
- Complete left bundle branch block
- Long QT syndrome or a known family history of long QT syndrome.
- Clinically significant resting bradycardia (<50 beats per minute)
- QTc > 450 msec on baseline ECG (using the QTcF formula). If QTcF >450 msec and electrolytes are not within normal ranges, electrolytes should be corrected and then the patient re-screened for QTc
- Myocardial infarction within 12 months prior to starting study
- Other clinically significant heart disease (e.g. unstable angina, congestive heart failure or uncontrolled hypertension).
- Female patients who are pregnant or breast-feeding.
- Patient has a severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic renal disease, or active uncontrolled infection).
- Patient has known chronic liver disease (i.e., chronic active hepatitis, and cirrhosis).
- Patient has a known diagnosis of human immunodeficiency virus (HIV) infection.
- Patient had a major surgery within 2 weeks prior to study entry.
- Patient with any significant history of non-compliance to medical regimens or with inability to grant reliable informed consent.
- Patients with active CNS disease (patients with history of CNS disease are allowed).
- Patients with pleural effusion or ascites
- Patients with a history of pancreatitis.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00750659
Israel | |
Chaim Sheba Medical Center | |
Tel-Hashomer, Israel, 52621 |
Principal Investigator: | Arnon Nagler, MD | Sheba Medical Center |
Responsible Party: | Sheba Medical Center |
ClinicalTrials.gov Identifier: | NCT00750659 |
Other Study ID Numbers: |
SHEBA-08-5288-AN-CTIL |
First Posted: | September 10, 2008 Key Record Dates |
Last Update Posted: | April 20, 2016 |
Last Verified: | April 2016 |
Chronic myeloid leukemia Ph+ acute lymphoblastic leukemia stem cell transplantation nilotinib |
Leukemia Leukemia, Myeloid Precursor Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Lymphoid Leukemia, Myelogenous, Chronic, BCR-ABL Positive Neoplasms by Histologic Type Neoplasms |
Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Myeloproliferative Disorders Bone Marrow Diseases Hematologic Diseases |