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Addition of Heparin to Taurolock-TM CLS in HD Patients With TCC Dose it Improve Catheter Patency Problems ?

This study has been completed.
Information provided by:
Western Galilee Hospital-Nahariya Identifier:
First received: September 7, 2008
Last updated: September 8, 2008
Last verified: September 2008
Addition of Heparin to the Catheter Lock Solution (CLS): Taurolock-TM will improve the vascular patency compared to Taurolock-TM alone , in hemodialysis patients with Tunneled Cuffed Catheter(TCC) as vascular access.

Condition Intervention Phase
End Stage Renal Disease
Other: Catheter Lock Solution Taurolidine and Citrate
Other: Catheter Lock Solution :Taurolidine and Citrate and Heparin
Other: Catheter Lock Solution : Heparin
Phase 3

Study Type: Interventional
Study Design: Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by Western Galilee Hospital-Nahariya:

Study Start Date: May 2007
Study Completion Date: August 2008
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A Other: Catheter Lock Solution Taurolidine and Citrate
Experimental: B Other: Catheter Lock Solution :Taurolidine and Citrate and Heparin
No Intervention: C Other: Catheter Lock Solution : Heparin

Detailed Description:

Bacteremia and thrombosis are the major complications of TCC used for hemodialysis.Instilation of CLS containing antibiotic-anticoagulant solution in the end of each dialysis session till the next dialysis ,can prevent Catheter related bacteremia (CRB).In previous study in our department, Taurolock-TM decreased the rate of CRB but increased the incidence of catheter malfunction.

The aim of the study is to investigate the influence of of Heparin addition to CLS-Taurolock- TM ( Taurolidine &citrate 4%) in prevention of catheter patency problems in HD patients with TCC, in addition to CRB prevention.

Methods : Patients with newly inserted TCC for HD enrolled and randomized to receive one of three CLS types : group 1- Taurolock-TM, Group 2 - Taurolock-TM and Heparin , Group 3- Heparin .Patients were followed for 6 monthes.

The objective of the study is to investigate the effect of Taurolock TM with heparin on the rate of CRB and vascular patency.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Hemodialysis patients with new TCC
  • Informed Consent
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Please refer to this study by its identifier: NCT00749619

Western Galilee Hospital
Nahariya, Israel
Sponsors and Collaborators
Western Galilee Hospital-Nahariya
  More Information Identifier: NCT00749619     History of Changes
Other Study ID Numbers: TAURO 070908
Study First Received: September 7, 2008
Last Updated: September 8, 2008

Keywords provided by Western Galilee Hospital-Nahariya:
Tunneled Cuffed Catheter
Catheter Lock Solution
Catheter Related Bacteremia

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Renal Insufficiency
Kidney Diseases
Urologic Diseases
Pharmaceutical Solutions
Calcium heparin
Citric Acid
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Anti-Infective Agents
Anti-Infective Agents, Local
Antineoplastic Agents
Calcium Chelating Agents
Chelating Agents
Sequestering Agents processed this record on May 25, 2017