Evaluation of Toxic Metals, Trace Elements and Total Antioxidant Activity in Children With Recurrent Wheezing
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|ClinicalTrials.gov Identifier: NCT00749528|
Recruitment Status : Completed
First Posted : September 9, 2008
Last Update Posted : March 15, 2012
|Condition or disease|
In many studies it was demonstrated that children are much more susceptible than adults for environmental toxic metal exposure. Hair analysis is a promising tool for routine clinical screening and diagnosis of heavy metal exposure and essential trace element states in the human body. Additionally it was demonstrated that oxidants and antioxidants play a central role in the pathogenesis of many pulmonary diseases including asthma. Furthermore, toxic metals, trace elements and oxidative stress have many pivotal role on immune system.
To evaluate and compare hair toxic metals, hair essential trace elements levels and plasma total antioxidant activity between children with recurrent wheezing and age and sex matched healthy children.
Intervention: Hair samples will be collected for the analysis of the toxic metals, trace elements. Blood samples will be collected for the analysis of the cytokine levels and plasma antioxidant activity.
Differences in hair toxic metals, hair trace elements, plasma cytokine levels and plasma total antioxidant activity will be compared between children with recurrent wheezing and age-sex matched healthy children
|Study Type :||Observational|
|Actual Enrollment :||95 participants|
|Observational Model:||Case Control|
|Official Title:||Sectional Prospective Randomised Study of Evaluation Toxic Metals, Trace Elements Status and Total Antioxidant Activity in Children With Recurrent Wheezing.|
|Study Start Date :||September 2007|
|Actual Primary Completion Date :||July 2008|
|Actual Study Completion Date :||July 2008|
Children vith recurrent wheezing
- Hair toxic metal and trace element status in the two groups [ Time Frame: 6 months ]
- To compare plasma total antioxidant activity in the two groups. [ Time Frame: 6 months ]
- Effect of heavy metals and trace elements on plasma cytokine levels and difference between the two groups [ Time Frame: 6 months ]
Biospecimen Retention: Samples Without DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00749528
|Kecioren Eğitim Araştırma Hastanesi|
|Ankara, Kecioren, Turkey, 06380|
|Study Director:||C H RAZI, MD||Kecioren Education and Training Hospital|
|Principal Investigator:||C H RAZI, MD||Kecioren Education and Training Hospital|