Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
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|ClinicalTrials.gov Identifier: NCT00748254|
Recruitment Status : Enrolling by invitation
First Posted : September 8, 2008
Last Update Posted : February 1, 2018
|Condition or disease||Intervention/treatment|
|Arthritis, Rheumatoid||Procedure: Laser Based Photoacoustic Tomography, MRI, Ultrasound Procedure: laser based photoacoustic tomography, MRI, ultrasound|
The objective of this proposal is to adapt photoacoustic tomography (PAT), a novel, nonionizing, noninvasive, laser-based technology, for structural and functional imaging of human peripheral joints affected by inflammatory arthritis.
Combining the advantages of both light and ultrasound scanning, PAT holds promise to present objective optical information in subsurface joint tissues with high sensitivity and high spatial resolution.
This could be of considerable help in the early detection of inflammatory joint diseases. PAT may also prove useful in further understanding the pathophysiology of these disorders and assisting with therapeutic decisions, including assessment of new pharmacological therapies.
|Study Type :||Observational|
|Estimated Enrollment :||120 participants|
|Official Title:||Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis|
|Study Start Date :||February 2008|
|Estimated Primary Completion Date :||January 2021|
|Estimated Study Completion Date :||January 2021|
Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound
Procedure: Laser Based Photoacoustic Tomography, MRI, Ultrasound
Healthy subjects will have scans on finger joints with any of the scanning methods described above.
Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand
Procedure: laser based photoacoustic tomography, MRI, ultrasound
Subjects with arthritis will have scans on finger joints with any of the scanning methods described above.
- Photoacoustic Imaging [ Time Frame: 2 weeks ]To determine if photoacoustic imaging (PAT) can accurately assist in the diagnosis of chronic rheumatoid arthritis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00748254
|United States, Michigan|
|Universtity of Michigan Health System|
|Ann Arbor, Michigan, United States, 48109|
|Principal Investigator:||Xueding Wang, Ph.D||University of Michigan|