Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.
Precisely, the study was designed to :
Set up a new model of Chronic Intermittent Hypoxia (CIH) applied to healthy human. This CIH is mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome.
Evaluate the cardiovascular effect of CIH. Neuronal and humoral sympathetic control, blood pressure control, vascular resistance.
Evaluate the Sleep quality, the ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex).
Investigates the biological aspects of CIH exposure.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects|
- Blood Pressure [ Time Frame: Two Weeks ] [ Designated as safety issue: No ]
- Neuronal and humoral sympathetic control and vascular resistance. [ Time Frame: Two weeks ] [ Designated as safety issue: No ]
- Sleep quality [ Time Frame: Two Weeks ] [ Designated as safety issue: No ]
- The ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex) [ Time Frame: two weeks ] [ Designated as safety issue: No ]
|Study Start Date:||September 2005|
|Estimated Study Completion Date:||October 2008|
|Primary Completion Date:||July 2007 (Final data collection date for primary outcome measure)|
Other: Chronic Intermittent Hypoxia
Please refer to this study by its ClinicalTrials.gov identifier: NCT00746928
|Pulmonary Function and sleep Lab, CHU Grenoble|
|Grenoble, France, 38 000|
|Principal Investigator:||Renaud Tamisier, MD, PhD||University Hospital, Grenoble|