Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00745888|
Recruitment Status : Unknown
Verified August 2009 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : September 3, 2008
Last Update Posted : September 9, 2009
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.
The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.
|Condition or disease||Intervention/treatment||Phase|
|Sepsis Shock||Other: Chemiluminescence Analyzer||Phase 3|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit|
|Study Start Date :||May 2007|
age > 18 y/o Patients admitted to surgical ICU
Other: Chemiluminescence Analyzer
measure reactive oxygen species
- 28-day Survival [ Time Frame: 28 days ]
- Days stay in ICU Days on ventilator SOFA score Complications [ Time Frame: 28 days ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00745888
|Contact: Yu-Chang Yeh, MDfirstname.lastname@example.org|
|National Taiwan University Hospital||Recruiting|
|Taipei, Taiwan, 100|
|Contact: Yu-Chang Yeh, MD 886-9-68661829 email@example.com|
|Principal Investigator: Yu-Chang Yeh, MD|
|Principal Investigator:||Yu-Chang Yeh||National Taiwan University Hospital|