We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00745888
Recruitment Status : Unknown
Verified August 2009 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 3, 2008
Last Update Posted : September 9, 2009
Information provided by:
National Taiwan University Hospital

Brief Summary:

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Condition or disease Intervention/treatment Phase
Sepsis Shock Other: Chemiluminescence Analyzer Phase 3

Study Type : Observational
Estimated Enrollment : 200 participants
Time Perspective: Prospective
Official Title: Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
Study Start Date : May 2007

Group/Cohort Intervention/treatment
age > 18 y/o Patients admitted to surgical ICU
Other: Chemiluminescence Analyzer
measure reactive oxygen species

Primary Outcome Measures :
  1. 28-day Survival [ Time Frame: 28 days ]

Secondary Outcome Measures :
  1. Days stay in ICU Days on ventilator SOFA score Complications [ Time Frame: 28 days ]

Biospecimen Retention:   Samples Without DNA
blood sample

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients admitted to surgical ICU

Inclusion Criteria:

  • Age > 18 y/o
  • Admitted to surgical ICU

Exclusion Criteria:

  • Patients with brain death

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00745888

Contact: Yu-Chang Yeh, MD 886-9-68661829 tonyyeh@ntuh.gov.tw

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Yu-Chang Yeh, MD    886-9-68661829    tonyyeh@ntuh.gov.tw   
Principal Investigator: Yu-Chang Yeh, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Yu-Chang Yeh National Taiwan University Hospital

Responsible Party: Yu-Chang Yeh, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00745888     History of Changes
Other Study ID Numbers: 9561709132
First Posted: September 3, 2008    Key Record Dates
Last Update Posted: September 9, 2009
Last Verified: August 2009

Keywords provided by National Taiwan University Hospital:
oxidative stress
intensive care
Postoperative intensive care