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The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2008 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: August 31, 2008
Last updated: September 2, 2008
Last verified: September 2008
Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from choroid plexus in the ventricle. If the SAH is too dense, the blood in the subarachnoid space will not easy to be washed out.

Subarachnoid Hemorrhage
Vasospasm, Intracranial

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Biospecimen Retention:   Samples With DNA

Estimated Enrollment: 20
Study Start Date: May 2008
Estimated Study Completion Date: September 2008
Detailed Description:
Cerebral vasospasm remains a significant source of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) after an aneurysmal rupture. Despite being a significant source of morbidity and mortality, death and disability from vasospasm have declined from approximately 35% in the early 1970's, to between 15% and 20% in the 1980's to <10% in the 1990's(1,2,3,4).Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product)(1,12,13). This mechanism appears to be a multifactorial process that involves the generation of free radicals, lipid peroxidation and activation of protein kinase C as well as phospholipase C and A2 with resultant accumulation of diacylglycerol and the release of endothelin-1(14,15,16,17,18). On the other hand, depletion of NO synthase (19,20,21) was also noted after SAH. Previous reports showed that shunting of CSF through a lumbar drain after an SAH markedly reduces the risk of clinically evident vasospasm and its sequelae, shortens hospital stay, and improves outcome. Its beneficial effects are probably mediated through the removal of spasmogens that exist in the CSF(22). In our preliminary data, we have demonstrated a case with severe vasospasm, CSF was collected both from EVD and lumbar drain. The ADMA level and amount of Nitrate was well correlate with vasospasm and the level was much higher in lumbar drain then EVD. So, we will compared the CSF from EVD and lumbar puncture to see which factor is correlate with vasospasm.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patient of spontaneous SAH

Inclusion Criteria:

  • Aneurysmal rupture with SAH

Exclusion Criteria:

  • Bleeding tendency,
  • Large ICH with impending herniation
  Contacts and Locations
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Please refer to this study by its identifier: NCT00745758

Contact: Kuo-Chuan Wang, MD 886-223123456 ext 5077

devision of neurosurgery, National taiwan university hospital Recruiting
Taipei, Taiwan, 112
Contact: Kuo-Chuan Wang, MD    886223123456   
Principal Investigator: Kuo-Chuan Wang, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Kuo-Chuan Wang, MD NTUH
  More Information

Responsible Party: Kuo-Chuan Wang, Devision of neurosurgery Identifier: NCT00745758     History of Changes
Other Study ID Numbers: 200803080R 
Study First Received: August 31, 2008
Last Updated: September 2, 2008
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
SAH, vasospasm, ADMA

Additional relevant MeSH terms:
Subarachnoid Hemorrhage
Vasospasm, Intracranial
Pathologic Processes
Intracranial Hemorrhages
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases processed this record on October 21, 2016